The ‘t Hart group at the Chemical Genomics Centre which is part of the Max Planck Institute of Molecular Physiology is looking for a PhD student (m/f/d) in chemical biology to join our highly multidisciplinary chemical biology team for the ERC-funded PRIGLUE project to look for molecular glues that stabilize protein-RNA interactions.
RNA-binding proteins play important roles in a wide variety of cellular processes and various diseases are caused by a loss of affinity between the RNA-binding protein and its RNA targets. The project aims to identify molecular glues that promote the interaction between the RBP and its RNA to compensate for this loss of affinity and provide a novel therapeutic strategy. The project will involve the use of an in-house developed protein-RNA interaction assay in combination with a genetically encoded cyclic peptide library screening technique. The powerful combination allows the high-throughput screening of a library with millions of cyclic peptides in a single experiment. Identified molecular glues will then be further evaluated in biochemical and cellular assays.
We are looking for an enthusiastic candidate who has recently finished a degree in biochemistry, chemical biology, chemistry, or a related topic. The candidate should have experience with molecular cloning, biochemistry, and cell biology.
The ‘t Hart group is a young and dynamic team of chemists and biologists. Our aim is to explore the use of macrocyclic peptides to address difficult targets with a focus on RNA biology. We also develop methods to improve peptide properties using novel chemical methodology. We offer state-of-the-art facilities including fully equipped peptide/organic synthesis labs and cell biology facilities.
The position is available from the 1st of June 2023 and fully funded for 3 years with the possibility for an extension for another year. Financial compensation will be carried out according to the public service remuneration scheme TVöD.
The Max Planck Society is committed to increasing the number of individuals with disabilities in its workforce and therefore encourages applications from such qualified individuals. The Max Planck Society strives for gender equality and diversity within its workforce. Furthermore, the Max Planck Society seeks to increase the number of women in those areas where they are underrepresented and therefore explicitly encourages women to apply.
Applications should be sent (as PDF) to Dr. Peter ‘t Hart peter.t-hart@mpi-dortmund.mpg.de . Applications should include a motivation letter, a recent CV, copies of your certificates, and two names for reference. The deadline for application is the 14.04.2023
For questions regarding the position please contact Dr. Peter ‘t Hart directly.
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