PhD fellowship in Genetic Epidemiology

 


We are offering a PhD fellowship in Genetic Epidemiology commencing September 1, 2022, or after agreement.

Background
CBMR is a vibrant international research environment with a focus on interdisciplinary collaboration. Our researchers share a common purpose as they seek to transform the basic understanding of the mechanisms involved in metabolic health and disease, and to accelerate this knowledge toward new prevention and treatment strategies. The Center’s research has resulted in seminal discoveries as to how genes, hormones, and environmental factors influence metabolic health and disease throughout life. You can read more about us here www.cbmr.ku.dk.

Our group and research
The Novo Nordisk Foundation Center for Basic Metabolic Research’s vision is to strengthen interdisciplinary research that transforms our basic understanding of the mechanisms that underlie metabolic health and disease, and to accelerate this knowledge toward new prevention and treatment strategies. We were established in 2010 and in 2017, we moved into new laboratories, offices, and meeting rooms in the Maersk Tower www.maersktower.ku.dk.

The Center has around 260 employees who work in an international, highly collaborative research environment across a range of biomedical disciplines. You can read more about us here www.cbmr.ku.dk.

The group
The Hansen Group investigates the human genome and the human global microbiome to characterize the impact of these genomes on health and disease and to identify interactions between the host and the microbiome. You can read more about the Hansen Group here.

Project description
We seek an enthusiastic, passionate researcher to perform a PhD project in Genetic Epidemiology. The main objective of the PhD project is to investigate the relationship between oral and metabolic health. The project will involve performing genome-wide association study, deriving polygenic risk scores (PRS) for selected oral diseases, and conducting mendelian randomization study to assess the causal relationships between oral and metabolic health. The PhD student will work with genetic, phenotype and registry data of various population-based cohorts.

Principal supervisor is Professor Torben Hansen, Novo Nordisk Foundation Center for Basic Metabolic Research, email: torben.hansen@sund.ku.dk

Start:                September 1, 2022, or after agreement

Duration:          3 years as a PhD student

Job description
Your key tasks as a PhD student at SUND are:

  • Carry through an independent research project under supervision
  • Complete PhD courses or other equivalent education corresponding to approx. 30 ECTS points
  • Participate in active research environments including a stay at another research team
  • Obtain experience with teaching or other types of dissemination related to your PhD project
  • Teach and disseminate your knowledge
  • Write a PhD thesis on the grounds of your project

Key criteria for the assessment of applicants
Applicants must have qualifications corresponding to a master’s degree related to the subject area of the project e.g., human biology, bioinformatics, molecular biology/biomedicine etc.

Other important criteria are:

  • Hands-on experience in genetic epidemiology methods, including genetic association analysis
  • Hands-on experience with cell counting of bacteria
  • Professional qualifications relevant to the PhD project, including statistical analysis methods and knowledge of coding languages, including R, bash, and python
  • Experience with working on a Linux server
  • Curious mind-set with active interest in the genetic epidemiology and the role of oral diseases on general and metabolic health will be an asset
  • Very good performance (= grade point average) in relative master’s degree
  • Dissemination activities, such as conference participation and poster presentations, will be seen as an advantage
  • Excellent communication skills in both written and spoken English

Place of employment
The place of employment is at the Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen. We offer creative and stimulating working conditions in dynamic and international research environment. Our research facilities include modern laboratories, bioinformatics and statistic guidance, and access to big data from multiple cohorts.

Terms of employment

The employment as PhD fellow is full time and for 3 years. The starting date is September 1, 2022, or after agreement.

It is conditioned upon the applicant’s success­ful enrolment as a PhD student at the Graduate School at the Faculty of Health and Medical Sciences, University of Copenhagen. This requires submission and acceptance of an application for the specific project formulated by the applicant.

The PhD study must be completed in accordance with The Ministerial Order on the PhD programme (2013) and the faculty’s rules on achieving the degree.

Salary, pension, and terms of employment are in accordance with the agree­ment between the Ministry of Finance and The Danish Confederation of Professional Associations on Academics in the State. Depending on seniority, the monthly salary begins around 26,957 DKK/approx. 3,618 EUR (April 2022 level) plus pension.

Questions
For specific information about the PhD fellowship, please contact the principal supervisor.

General information about PhD study at the Faculty of Health and Medical Sciences is available at the Graduate School’s website: https://healthsciences.ku.dk/phd/guidelines/.

Application procedure
Your application must be submitted electronically by clicking ‘Apply now’ below. The application must include the following documents in PDF format: 

  1. Motivated letter of application (max. one page)
  2. CV incl. education, experience, language skills and other skills relevant for the position
  3. Certified copy of original Master of Science diploma and transcript of records in the original language, including an authorized English translation if issued in other language than English or Danish. If not completed, a certified/signed copy of a recent transcript of records or a written statement from the institution or supervisor is accepted. As a prerequisite for a PhD fellowship employment, your master’s degree must be equivalent to a Danish master’s degree. We encourage you to read more in the assessment database: https://ufm.dk/en/education/recognition-and-transparency/find-assessments/assessment-database. Please, note that we might ask you to obtain an assessment of your education performed by the Ministry of Higher Education and Science
  4. Publication list (if possible)

Application deadline: June 2, 2022, at 23.59pm CET.

We reserve the right not to consider material received after the deadline, and not to consider applications that do not live up to the abovementioned requirements.

The further process
After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the hiring committee. All applicants are then immediately notified whether their application has been passed for assessment by an unbiased assessor.

The assessor makes a non-prioritized assessment of the academic qualifications and experience with respect to the above-mentioned area of research, techniques, skills, and other requirements listed in the advertisement.

Once the assessment work has been completed each applicant can comment on the part of the assessment that relates to the applicant him/herself.

You may read about the recruitment process at https://employment.ku.dk/faculty/recruitment-process/.

The applicant will be assessed according to the Ministerial Order no. 242 of 13 March 2012 on the Appointment of Academic Staff at Universities.

The University of Copenhagen wishes to reflect the diversity of society and welcome applications from all qualified candidates regardless of personal background.

APPLY NOW

Part of the International Alliance of Research Universities (IARU), and among Europe’s top-ranking universities, the University of Copenhagen promotes research and teaching of the highest international standard. Rich in tradition and modern in outlook, the University gives students and staff the opportunity to cultivate their talent in an ambitious and informal environment. An effective organisation – with good working conditions and a collaborative work culture – creates the ideal framework for a successful academic career.

Contact

Torben Hansen

Info

Application deadline: 02-06-2022
Employment start: 01-09-2022
Working hours: Full time
Department/Location: Novo Nordisk Foundation Center for Basic Metabolic Research

PhD fellowship in applied statistics in monitoring pesticide effects

 


Department of Plant and Environmental Sciences, Crop Science invites applicants for a "PhD fellowship in dynamic statistical modelling of toxic effects in herbicide exposed plants". The project is part of the research project “Enhancing statistical methodology for toxicophenomics: High-throughput and high-dimensional data for ecotoxicological risk assessment”, which is financed by the Novo Nordic Foundation.

Start date is (expected to be) October 1st 2022 or as soon as possible thereafter.

The project
The main aim of environmental risk assessment is to assign magnitudes and probabilities to adverse effects of human impact. A key parameter used in chemical risk assessment is the benchmark dose, identifying the dose associated with a predefined deviation from non-treated controls in the testsystem investigated. The benchmark dose methodology relies on non-linear dose-response models. The methodology is well-established for univariate data, such as a growth or mortility measured at a single point in time, but less so for more complex data structures such hierarchical data based on repeated experiments or time series, which have the advantage of closer resembling reality and accordingly provide more valuable input for risk assessments.  In addition, as toxicity is a process in time and exposure concentrations often vary in time (chemicals degrade in the environment, and/or are added repeatedly), statistical methods to describe effect development in time as a function of exposure is becoming increasingly important tools for chemical risk assessment.

The primary focus of the PhD project will be on extending existing dose-response models for univariate data to different types of multivariate data, incorporating the time perspective of toxicity development. The key challenges are 1) developing dose-response models applicable to data from complex hierarchical designs, 2) testing and developing statistical models for toxic effects in time and 3) testing and developing models for dynamic exposure data

The solution to these challenges rely on nonlinear optimization, mixed-effects models, the use of differential equations to incorporate the time aspect and a combination of all. Exploration and validation of the developed methodology to real experimental data and implementation is an important aspect of the project.

Who are we looking for?
We are looking for a candidate with strong competences within the field(s) of statistics and data science. Applicants can have a background in statistics, mathematics, environmental modeling, or environmental toxicology with flair and interest in statistics and data science. The applicant should also be prepared to do some experimental work to produce own data.

Our group and research- and what do we offer?

The successful applicant will be part of a new research group focusing on applied statistics within agronomy, eco-toxicology and phenotyping. We are a part of the crop science section and work closely together with reasearchers across the section, inparticular the plant protection group https://plen.ku.dk/english/research/crop_sciences/pp/. The crop science section studies and teaches basic and applied sciences related to crop production, with a focus on the interaction between Genotype, Management and Environment.  The aim of the crop science section is to improve land management for sustainable food production in a changing climate, by conducting research in laboratories, greenhouses, semi-field and fields. The applied statistics group also works closely together with the environmental toxicology group https://plen.ku.dk/english/research/env_chem_phys/et/. This group focuses on the effects of chemical pollutants on individual organisms, populations and ecosystems. Combined, our research projects are closely connected to national and international plant breeders, the agricultural industry, and Danish and European regulatory authorities concerned with the risk assessment of pesticides and industrial chemicals. 

The group is a part of Department of Plant and Environmetal Science, Faculty of SCIENCE, University of Copenhagen. We are located in Taastrup, Copenhagen.

We offer creative and stimulating working conditions in dynamic and international research environment.

Principal supervisor is Assistant Professor, Signe M. Jensen, Department of Plant and Environmental Sciences, smj@plen.ku.dkDirect Phone: +4535333431. Co-superviser: Professor, Nina Cedergreen, Department of Plant and Environmental Sciences. 

The PhD programme

Depending of your level of education, you can undertake the PhD programme as either:

Option A: three year full-time study within the framework of the regular PhD programme (5+3 scheme)if you already have an education equivalent to a relevant Danish master’s degree.

Option B: An up to five year full-time study programme within the framework of the integrated MSc and PhD programme (the 3+5 scheme), if you do not have an education equivalent to a relevant Danish master´s degree – but you have an education equivalent to a Danish bachelors´s degree.

Option A: Getting into a position on the regular PhD programme

Qualifications needed for the regular programme
To be eligible for the regular PhD programme, you must have completed a degree programme, equivalent to a Danish master’s degree (180 ECTS/3 FTE BSc + 120 ECTS/2 FTE MSc) related to the subject area of the project, e.g. statistics, mathematics, environmenal modeling, or environmental toxicology. For information of eligibility of completed programmes, see General assessments for specific countries and Assessment database.

Terms of employment in the regular programme
Employment as PhD fellow is full time and for maximum 3 years.

Employment is conditional upon your successful enrolment as a PhD student at the PhD School at the Faculty of SCIENCE, University of Copenhagen. This requires submission and acceptance of an application for the specific project formulated by the applicant.

The terms of employment and salary are in accordance to the agreement between the Ministry of Finance and The Danish Confederation of Professional Associations on Academics in the State (AC). The position is covered by the Protocol on Job Structure.

Option B: Getting into a position on the integrated MSc and PhD programme

Qualifications needed for the integrated MSc and PhD programme

If you do not have an education equivalent to a relevant Danish master´s degree, you might be qualified for the integrated MSc and PhD programme, if you have an education equivalent to a relevant Danish bachelor´s degree. Here you can find out, if that is relevant for you: General assessments for specific countries and Assessment database.  

Terms of the integrated programme
To be eligible for the integrated scholarship, you are (or are eligible to be) enrolled at one of the faculty’s master programmes in statistics.

Students on the integrated programme will enroll as PhD students simultaneously with completing their enrollment in this MSc degree programme.

The duration of the integrated programme is up to five years, and depends on the amount of credits that you have passed on your MSc programme. For further information about the study programme, please see: www.science.ku.dk/phd, “Study Structures”. 

Until the MSc degree is obtained, (when exactly two years of the full 3+5 programme remains), the grant will be paid partly in the form of 48 state education grant portions (in Danish: “SU-klip”) plus salary for work (teaching, supervision etc.) totalling a workload of 150 working hours per year.

When you have obtained the MSc degree, you will transfer to the salary-earning part of the scholarship for a period of two years. At that point, the terms of employment and payment will be according to the agreement between the Ministry of Finance and The Danish Confederation of Professional Associations on Academics in the State (AC). The position is covered by the Protocol on Job Structure.
A PhD grant portion is currently (2021) DKK 6.321 before tax.

Responsibilities and tasks in both PhD programmes

  • Complete and pass the MSc education in accordance with the curriculum of the MSc programme   (ONLY when you are attending the integrated MSc and PhD programme)
  • Carry through an independent research project under supervision 
  • Complete PhD courses corresponding to approx. 30 ECTS / ½ FTE
  • Participate in active research environments, including a stay at another research institution, preferably abroad
  • Teaching and knowledge dissemination activities
  • Write scientific papers aimed at high-impact journals
  • Write and defend a PhD thesis on the basis of your project

We are looking for the following qualifications:

  • Professional qualifications relevant to the PhD project, i.e. qualifications within statistics and good programming skills.
  • Relevant publications within the areas of statistics, modelling or toxicology
  • Relevant work experience
  • Other relevant professional activities
  • Curious mind-set with a strong interest in applied statistics and R programming skills
  • Good written and spoken English language skills

Application and Assessment Procedure

 Your application including all attachments must be in English and submitted electronically by clicking APPLY NOW below.

Please include

  1. Motivated letter of application (max. one page)
  2. Your motivation for applying for the specific PhD project
  3. Curriculum vitae including information about your education, experience, language skills and other skills relevant for the position
  4. Original diplomas for Bachelor of Science or Master of Science and transcript of records in the original language, including an authorized English translation if issued in another language than English or Danish. If not completed, a certified/signed copy of a recent transcript of records or a written statement from the institution or supervisor is accepted.
  5. Publication list (if possible)
  6. Reference letters (if available)

Application deadline:

The deadline for applications is Monday  6 June 2022, 23:59 GMT +2.

We reserve the right not to consider material received after the deadline, and not to consider applications that do not live up to the abovementioned requirements.

The further process
After deadline, a number of applicants will be selected for academic assessment by an unbiased expert assessor. You are notified, whether you will be passed for assessment.

The assessor will assess the qualifications and experience of the shortlisted applicants with respect to the above mentioned research area, techniques, skills and other requirements. The assessor will conclude whether each applicant is qualified and, if so, for which of the two models. The assessed applicants will have the opportunity to comment on their assessment. You can read about the recruitment process at https://employment.ku.dk/faculty/recruitment-process/.

Interviews with selected candidates are expected to be held in mid August.

Questions
For specific information about the PhD fellowship, please contact the principal supervisor Signe M. Jensen, smj@plen.ku.dkDirect Phone: +4535333431.

General information about PhD study at the Faculty of SCIENCE is available at the PhD School’s website: https://www.science.ku.dk/phd/.

The University of Copenhagen wishes to reflect the surrounding community and invites all regardless of personal background to apply for the position.  

APPLY NOW

Part of the International Alliance of Research Universities (IARU), and among Europe’s top-ranking universities, the University of Copenhagen promotes research and teaching of the highest international standard. Rich in tradition and modern in outlook, the University gives students and staff the opportunity to cultivate their talent in an ambitious and informal environment. An effective organisation – with good working conditions and a collaborative work culture – creates the ideal framework for a successful academic career.

Contact

Signe Marie Jensen

Info

Application deadline: 06-06-2022
Employment start: 01-10-2022
Working hours: Full time
Department/Location: Department of Plant and Environmental Sciences

PhD fellowship in ”Fibrosis and intracellular calcium handling in the pathophysiology of heart failure with preserved ejection fraction”

 


A PhD position is available in the Cardiac Electrophysiology Group at the Faculty of Health and Medical Sciences, University of Copenhagen, Denmark. The position is available from September 1st, 2022, or at a mutually agreed date. Very motivated and committed candidates with experience in cardiovascular physiology and animal models of human disease are invited to apply.

The employment as PhD fellow is full time and for 3 years. The position is fully funded and is conditioned upon the applicant’s successful enrollment as a PhD student at the Graduate School at the Faculty of Health and Medical Sciences, University of Copenhagen. This requires submission and acceptance of an application for the specific project formulated by the applicant.

 

Project description

Heart failure is a critical, clinical diagnosis characterized by shortness of breath at rest, fatigue, weakness and edema. Two categories of heart failure exists: Heart failure with reduced or with preserved ejection fraction (HFrEF and HFpEF, respectively). A weakened heart muscle causes HFrEF, whereas HFpEF hearts are too stiff to be filled sufficiently during diastole. Historically, focus has been on HFrEF, but HFpEF represents an unmet medical need due to the unknown underlying causes, and the lack of efficient, clinical treatment options.

The student will use an integrated approach – both cellular, intact organ and whole-animal experiments – to test novel treatment options for HFpEF. Ultrasound-based echocardiography can be applied to follow the development of heart failure in the individual animal. Isolated, beating hearts can be used to gauge the effect of changes in filling pressure. Histology tests fibrosis development and fluorescent dyes can be used to visualize the intracellular calcium handling in disaggregated cardiomyocytes.

We are looking for an exceptional candidate with a flair for animal experiments. One that will be able to master many skills in the laboratory using whole animals, intact organs and isolated cells.

Supervision

Principal supervisor is Associate Professor Morten B Thomsen.

Primary co-supervisor is Associate Professor Jens C Brings Jacobsen

Start

October 1st 2022 or soon thereafter

Job description

Your key tasks as a PhD student at are:

  • Plan, execute and evaluate independent research under supervision
  • Complete PhD courses or equivalent education corresponding to 30 ECTS points
  • Teach pregraduate students
  • Disseminate your research orally and written
  • Write a PhD thesis on the grounds of your project

Criteria for the assessment of candidates

We evaluate the candidates primarily based on the following criteria:

  • You must have qualifications corresponding to a master’s degree related to the subject area of the project i.e. physiology, biology, bioengineering, medicine, human biology, veterinary medicine, molecular biomedicine or similar.
  • Experience with animal (rodents) experiments is very desirable. Prior skills in animal experiments are preferred, but not required. The candidate will perform surgery (blood-vessel cannulation) and harvest organs for experimental purposes. The candidate should be able to master the procedures within the first few months after being accepted into the program.
  • Experience with echocardiography, isolated heart studies e.g. Langendorff or calcium imaging is highly meriting.
  • Basic knowledge of cardiac electrophysiology and hemodynamics
  • High proficiency in English is a benefit.

Place of employment

The place of employment is at Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen. We offer creative and stimulating working conditions in a dynamic and international research environment with many research groups. Our research facilities include state-of-the-art laboratories supported by several core facilities.

Terms of employment

Employment as PhD fellow is full time and for maximum 3 years.

Employment is conditional upon your successful enrolment as a PhD student at the PhD School at the Faculty of Health and Medical Sciences, University of Copenhagen. This requires submission and acceptance of an application for the specific project formulated by the applicant.

The terms of employment and salary are in accordance to the agreement between the Ministry of Finance and The Danish Confederation of Professional Associations on Academics in the State (AC).

Questions

For specific questions relating to the PhD project, please contact the principal supervisor Associate Professor Morten B Thomsen (mbthom@sund.ku.dk). General information about PhD programs at the Faculty of Health and Medical Sciences is available at the Graduate School’s website: https://healthsciences.ku.dk/phd/

 

Application and Assessment Procedure

Your online application including all attachments must be in English and submitted electronically by clicking APPLY NOW below.

Please include:

  • Motivated letter of application (max. two pages)
  • Curriculum vitae focused on the assessment criterias outlines above. Include information about your education, laboratory experience, language skills and other skills relevant for the position. Please include a photo.
  • Certified copy of original Master of Science diploma and transcript of records in the original language, including an authorized English translation if issued in other language than English or Danish. If not completed, a certified/signed copy of a recent transcript of records or a written statement from the institution or supervisor is accepted. As a prerequisite for a PhD fellowship employment, your master’s degree must be equivalent to a Danish master’s degree. We encourage you to read more in the assessment database: https://ufm.dk/en/education/recognition-and-transparency/find-assessments/assessment-database. Please note that we might ask you to obtain an assessment of your education performed by the Ministry of Higher Education and Science.
  • Publication list (if possible)
  • Reference letters (if available)

Application deadline

Application deadline is June 15th, 2022. We will not consider material received after the deadline, and will not to consider applications that do not live up to the abovementioned requirements.

After the expiry of the deadline for applications, the recruitment manager selects applicants for assessment on the advice of the hiring committee. All applicants are then immediately notified whether their application has been passed for assessment by an unbiased assessor.

The assessor makes a non-prioritized assessment of the academic qualifications and experience with respect to the above-mentioned area of research, techniques, skills and other requirements listed in the advertisement. Once the assessment work has been completed each applicant has the opportunity to comment on the part of the assessment that relates to the applicant him/herself.

The applicants will be assessed according to the Ministerial Order no. 242 of 13 March 2012 on the Appointment of Academic Staff at Universities

Interviews are expected to be held in week 30, 2022

The University of Copenhagen wish to reflect the diversity of society and encourage all qualified candidates to apply regardless of personal background.

APPLY NOW

Part of the International Alliance of Research Universities (IARU), and among Europe’s top-ranking universities, the University of Copenhagen promotes research and teaching of the highest international standard. Rich in tradition and modern in outlook, the University gives students and staff the opportunity to cultivate their talent in an ambitious and informal environment. An effective organisation – with good working conditions and a collaborative work culture – creates the ideal framework for a successful academic career.

Contact

Morten Bækgaard Thomsen

Info

Application deadline: 15-06-2022
Employment start: 01-10-2022
Working hours: Full time
Department/Location: Biomedicinsk Institut

PhD fellowship in pharmaceutical sciences at Department of Drug Design and Pharmacology

 


We are offering a three-year PhD fellowship in pharmaceutical sciences commencing 19 September 2022 or as soon as possible thereafter.

Project description
Neurological disorders constitute the third leading cause of premature mortality in Europe, and represent one of the greatest therapeutic challenges of our time. They are in part related to dysfunctions or imbalances in the signalling and regulatory processes mediated by the two key neuromodulators, glycine and glutamine. We aim to reveal the molecular details of glycine and glutamine transport by their respective solute carrier (SLC) transporters, as well as the molecular basis for ligand-mediated and autoregulatory modulation of the targets. The applicant will use a multidisciplinary approach including structural studies by cryo-electron microscopy and/or X-ray crystallography, and a range of biophysical and biochemical methods.

Supervisors
Professor Michael Gajhede, Department of Drug Design and Pharmacology
Assistant Professor Azadeh Shahsavar, Department of Drug Design and Pharmacology
E-mail: ash@mbg.au.dk, from 1 July 2022: ash@sund.ku.dk, direct phone: +45 42 22 25 92.

Start
19 September 2022

Duration
3 years as a PhD student

Our group and research
The Shahsavar Lab (aka ASH-Lab) is a newly established research group at the University of Copenhagen, led by Assistant Prof. Azadeh Shahsavar. The lab studies human membrane proteins involved in transport of amino acids, charactering their structure, function and mechanism of regulation. The research will open new lines of possibility for tuning synaptic signalling through manoeuvring amino acid transporters, delineating their therapeutic potential.

The lab uses Insect cells and mammalian expression systems to recombinantly express the target proteins and employs serial synchrotron crystallography (SSX) and single-particle cryo-electron microscopy (cryo-EM) combined with biochemical and biophysical methods for structural and functional characterizations.

The funds supporting the ASH-Lab are provided by Lundbeck Foundation.

Our department
The Department of Drug Design and Pharmacology (www.drug.ku.dk) delivers drug-related research and research-based teaching within a wide range of drug-related disciplines, spanning the molecular, cellular, and pharmacological levels.

Job description
Your key tasks as a PhD student at the Faculty of Health and Medical Sciences are:

  • Carrying through an independent research project under supervision
  • Completing PhD courses or other equivalent education corresponding to approximately 30 ECTS points
  • Participating in active research environments including a stay at another research team, preferably abroad
  • Obtaining experience with teaching or other types of dissemination related to your PhD project
  • Teaching of undergraduate students in pharmaceutical sciences
  • Writing a PhD thesis on the grounds of your project

Key criteria for the assessment of applicants
Applicants must have qualifications corresponding to a master’s degree related to the subject area of the project, e.g., protein biochemistry or related area. Please note that your master’s degree must be equivalent to a Danish master’s degree (two years).

Other important criteria are:
We expect you to be a highly motivated and ambitious scientist with the following qualifications:

  • Professional qualifications relevant to the PhD project including: 
  • Experience in protein expression and purification techniques for structural and functional studies.
  • Experience in cryo-EM sample preparation and/or protein crystallization, data collection and analysis, including the use of relevant software.
  • Adapt existing and develop new scientific techniques and experimental protocols for analysis of membrane protein function, including cell-based and liposome-based techniques.
  • Other relevant work experience
  • Previous publications
  • The grade point average achieved
  • Other professional activities
  • A curious mind-set with a strong interest in understanding the molecular mechanisms of proteins function 
  • Proven ability to design, execute and analyse data from structural /biochemical/ biophysical experiments.
  • A high degree of personal responsibility and willingness to engage in problem-solving  
  • Language skills 
  • Proven communication and interpersonal skills, including the ability to write for publication, and present research proposals and results.

Terms of employment
The average weekly working hours are 37 hours per week.the position is a fixed-term position limited to a period of 3 years.

The employment is conditioned upon the applicant’s successful enrolment as a PhD student at the Graduate School at the Faculty of Health and Medical Sciences, University of Copenhagen. This requires submission and acceptance of an application for the specific project to the Graduate School of Health and Medical Sciences.

The PhD study must be completed in accordance with The Ministerial Order on the PhD programme (2013) and the Faculty’s rules on achieving the degree.

The PhD student is expected to be affiliated to the graduate programme in pharmaceutical sciences, 

Drug Research Academy.

Salary, pension, and terms of employment are in accordance with the agreement between the Ministry of Finance and The Danish Confederation of Professional Associations on Academics in the State. Depending on seniority, the monthly salary starts at approximately 28,300 DKK/roughly 3,770 EUR (April 2022 level) plus pension.

Application procedure
Your application, in English, must be submitted electronically by clicking “Apply now” below and must include the following documents in PDF format:

  • Motivated letter of application (max. one page)
  • CV incl. education, experience, language skills and other skills relevant for the position
  • Certified copy of original Master of Science diploma and transcript of records in the original language, including an authorized English translation if issued in other language than English or Danish. If not completed, a certified/signed copy of a recent transcript of records or a written statement from the institution or supervisor is accepted.
    As a prerequisite for a PhD fellowship employment, your master’s degree must be equivalent to a Danish master’s degree. We encourage you to read more in the assessment database: https://ufm.dk/en/education/recognition-and-transparency/find-assessments/assessment-database. Please note that we might ask you to obtain an assessment of your education performed by the Ministry of Higher Education and Science.
    Applicants with a Master´s degree from abroad should also enclose a short description of the grading scale used
  • Publication list (if possible)
  • Other information to consider: References and recommendations (if possible)

The deadline for applications is Sunday 19 June 2022, 23.59pm CET

We reserve the right not to consider material received after the deadline, and not to consider applications that do not live up to the abovementioned requirements.

The further process
After the expiry of the deadline for applications, the authorised recruitment manager selects applicants for assessment on the advice of the hiring committee. All applicants are then immediately notified whether their application has been passed for assessment by an unbiased assessor.

The assessor makes a non-prioritized assessment of the academic qualifications and experience with respect to the above-mentioned area of research, techniques, skills and other requirements listed in the advertisement.

Once the assessment work has been completed each applicant has the opportunity to comment on the part of the assessment that relates to the applicant him/herself.

The applicant will be assessed according to the Ministerial Order no. 242 of 13 March 2012 on the Appointment of Academic Staff at Universities.

Interviews are expected to be held in week 27.

You can read about the recruitment process at https://employment.ku.dk/faculty/recruitment-process/

Questions
For further information, applicants may contact the supervisor Azadeh Shahsavar, e-mail:  ash@mbg.au.dk, from 1 July 2022: ash@sund.ku.dk, direct phone: +45 42 22 25 92, or PhD coordinator Marianne W. Jørgensen, e-mail: marianne.joergensen@sund.ku.dk, direct phone: +45 3533 6449.

General information about PhD studies at the Faculty of Health and Medical Sciences is available at the Graduate School’s website: https://healthsciences.ku.dk/phd/guidelines/.

For more information on working and living in Denmark visit http://ism.ku.dk (International staff mobility) and https://www.workindenmark.dk.

The University of Copenhagen wish to reflect the diversity of society and encourage all qualified candidates to apply regardless of personal background.

APPLY NOW

Part of the International Alliance of Research Universities (IARU), and among Europe’s top-ranking universities, the University of Copenhagen promotes research and teaching of the highest international standard. Rich in tradition and modern in outlook, the University gives students and staff the opportunity to cultivate their talent in an ambitious and informal environment. An effective organisation – with good working conditions and a collaborative work culture – creates the ideal framework for a successful academic career.

Info

Application deadline: 19-06-2022
Employment start: 19-09-2022
Working hours: Full time
Department/Location: Department of Drug Design and Pharmacology

PhD fellowship in Structural Biology of Mitochondrial RNA Maturation at Novo Nordisk Foundation Center for Protein Research

 


The newly established research group of Eva Kummer is looking for an excellent and highly motivated PhD candidate to investigate how mitochondria produce and regulate diverse RNA species essential for mitochondrial gene expression. Before entering the fully funded 3-year PhD fellowship, the successful candidates will have an initial employment as Research assistant for 1 year scheduled to start 1 October 2022 or soon after.

About us
Kummer group is part of Novo Nordisk Foundation Center for Protein Research (CPR) that was established in 2007 at the Faculty of Health and Medical Sciences, University of Copenhagen, to promote basic and applied research. The center hosts research groups of different disciplines ranging from systems biology, proteomics, and chemical biology to disease biology. 
The primary methodological approaches of our laboratory are single particle cryo-electron microscopy and protein and RNA biochemistry. Our group profits from generous funding by an NNF-CPR core grant and a Hallas Møller Emerging Investigator grant from the Novo Nordisk Foundation. We have access to state-of-the-art electron and light microscopy infrastructure at CFIM (Core Facility for Integrated Microscopy at the University of Copenhagen). You will join a collaborative and international work environment. 

About the PI
Eva Kummer has strong expertise in protein and RNA biochemistry as well as electron microscopy. After a PhD in biochemistry on mechanisms of protein quality control in bacteria and yeast, her latest research has focused on unraveling mammalian mitochondrial translation mechanisms. For this, she has combined in vitro reconstitution approaches with single-particle cryo-EM. Examples of her work include:

Project Description
The PhD candidate will focus on RNA processing machines in mitochondria using in vitro and in vivo reconstitution approaches coupled with structural analysis by single particle cryo-EM and functional studies. Our group is part of the Protein Structure and Function (PSF) Program at NNF-CPR that also contains the groups of Guillermo Montoya (Program Director) and Nicholas Taylor. We have access to state-of-the-art electron microscopy instrumentation including a Titan Krios and a Glacios both equipped with Falcon III DED, as well as multiple smaller screening instruments. Moreover, the PSF program entertains an in-house GPU cluster for data processing. In addition, the candidate can profit from a number of CPR core facilities including protein production, crystallography, biophysics, high performance computing, mass spectrometry, and genomics.

Required qualifications  
We are looking for a highly motivated candidate with strong team player skills. As an applicant you must have: 

  • Obtained (or expect to have obtained) a Master’s degree (equivalent to a Danish Master’s degree) in Biology, Biochemistry, Biophysics or related areas prior to the starting date 
  • Fluency in English and excellent written and oral communication skills   

As a PhD candidate, you will have the opportunity to work on an interesting and challenging project that will profit from your enthusiasm and willingness to learn and implement new methodology. 

Preferred qualifications 
We are especially interested in candidates with previous experience in protein purification and electron microscopy or other structural techniques, although all necessary training will be provided to help you succeed. 
 
Job description 
During the first year as Research assistant, the candidate will have to formulate a PhD project, help out with research tasks and start become familiar with the research field of interest and apply for enrolment as PhD fellow.

Your key tasks as a PhD fellow at the Faculty are to: 

  • Carry through an independent research project under supervision 
  • Write scientific articles and the PhD thesis on the grounds of your research project 
  • Complete PhD courses or other equivalent education corresponding to approx. 30 ECTS points 
  • Obtain experience with teaching or other types of dissemination related to your PhD project 
  • Participate in national and international congresses and scientific meetings  
  • Stay at an external research institution, preferably abroad  

Terms of employment

The employment as Research assistant is full time and for 1 year. 
Salary, pension and terms of employment are in accordance with the agree¬ment between the Ministry of Finance and The Danish Confederation of Professional Associations on Academics in the State. Depending on seniority, the monthly salary begins around 30,470DKK /approx. 4,090 EUR(April 2022-level) plus pension.

The employment as PhD fellow is full time and for 3 years. 

It is conditioned upon the applicant’s successful enrolment as a PhD student at the Graduate School at the Faculty of Health and Medical Sciences, University of Copenhagen, as well as a positive assessment of the 1-year research assistant position. Enrolment at the Graduate School requires submission and acceptance of an application for the specific project formulated by the applicant (for more information, please see (https://healthsciences.ku.dk/phd/guidelines/).

The PhD study must be completed in accordance with The Ministerial Order on the PhD programme (2019) and the Faculty’s rules on achieving the degree. Salary, pension and terms of employment are in accordance with the agreement between the Ministry of Finance and The Danish Confederation of Professional Associations on Academics in the State. Depending on seniority, the monthly salary begins around 28,360DKK /approx. 3,811 EUR (April 2022-level) plus pension.

Questions
For informal inquiries please contact the principal investigator Associate professor Eva Kummer via eva.kummer@cpr.ku.dk. For administrative information please contact the HR Center, sund-hr-cpr@sund.ku.dk.
 
Application procedure
Your application must be submitted electronically by clicking ‘Apply now’ below. The application must include the following documents in PDF format: 
Letter of motivation 
CV incl. contact details of 2-3 references and a complete list of publications, if applicable
Transcripts of university studies (BSc and MSc, showing individual grades). If the MSc has not yet been completed, a certified/signed copy of a recent transcript of records or a written statement from the institution or supervisor will be fine. As a prerequisite for a PhD fellowship employment, your master’s degree must be equivalent to a Danish master’s degree. We encourage you to read more in the assessment database: https://ufm.dk/en/education/recognition-and-transparency/find-assessments/assessment-database. Please note that we might ask you to obtain an assessment of your education performed by the Ministry of Higher Education and Science

Application deadline: 19 June 2022, 23.59pm CET.

We reserve the right not to consider material received after the deadline, and not to consider applications that do not live up to the abovementioned requirements.

The further process
After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the hiring committee. All applicants are then immediately notified whether their application has been passed for assessment by an unbiased assessor.
The assessor makes a non-prioritized assessment of the academic qualifications and experience with respect to the above-mentioned area of research, techniques, skills and other requirements listed in the advertisement.
Once the assessment work has been completed each applicant has the opportunity to comment on the part of the assessment that relates to the applicant him/herself.

You can read about the recruitment process at https://employment.ku.dk/faculty/recruitment-process/.

The applicant will be assessed according to the Ministerial Order no. 1443 of 11 December 2020 on the Appointment of Academic Staff at Universities.

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Part of the International Alliance of Research Universities (IARU), and among Europe’s top-ranking universities, the University of Copenhagen promotes research and teaching of the highest international standard. Rich in tradition and modern in outlook, the University gives students and staff the opportunity to cultivate their talent in an ambitious and informal environment. An effective organisation – with good working conditions and a collaborative work culture – creates the ideal framework for a successful academic career.

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Eva Kummer

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Application deadline: 19-06-2022
Employment start: 01-10-2022
Working hours: Full time
Department/Location: Novo Nordisk Foundation Center for Protein Research

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