Postdoc in enzymatic upgrading of lignocellulose polymers

 

Our current climate emergency demands the transition to a biobased and circular economy, where multiple end products can be derived from renewable biomass resources. The postdoctoral researcher will be involved in the BioUPGRADE project “Biocatalytic upgrading of natural biopolymers for reassembly as multipurpose materials” under the program Future Emerging Technologies (FET Open) funded by the European Commission. The radical vision of BioUPGRADE is to integrate functional genomics and material science advances, to transform nature’s major structural polymers into a cascade of high volume and specialized bioproducts. The successful candidate is expected to be an active part of the consortium participating in all activities programmed by the coordinators of the project including research, meetings, dissemination, organization, student guidance, amongst others.

The postdoctoral researcher will participate in the surface functionalization of biofibres using biocatalytic tools towards applications in health and personal care. The candidate will investigate the effect of the biocatalytic modifications on the assembly and multiscale hierarchical organization of the lignocellulosic biofibres. The approach will include structural analysis of the functionalized biofibres using solid-state characterization techniques (e.g. microscopy, scattering and spectroscopy), together with characterization of the macroscopic properties (e.g. mechanical and rheological) of the derived materials.

The other partners in the BioUPGRADE project include Prof. Emma Master at Aalto University (Finland), Prof. Raúl Pérez-Jiménez at Nanoscience Cooperative Research Center CIC nanoGUNE (Spain) and Dr. Janak Sapkota at UPM-KYMMENE (Finland)

What we offer

• A position at a leading technical university that generates knowledge & skills for a sustainable future
• Engaged & ambitious colleagues along with a creative, international and dynamic working environment
• Works in Stockholm, in close proximity to nature
• Help to relocate and be settled in Sweden and at KTH
• The Postdoc. will be a part of the Division of Glycoscience at the Department of Chemistry at KTH, read more here. The Postdoc. will be part as well of Treesearch (Swedish National Infrastructure for New Materials from Trees) which offers a wide network of academia and industry.

Read more about what it is like to work at KTH

Qualifications

Requirements

• A doctoral degree or an equivalent foreign degree in polymer technology, material sciences, nanotechnology, biotechnology or related disciplines, obtained within the last three years prior to the application deadline (with some exceptions for special reasons such as periods of sick or parental leave, kindly indicate if such reason exists in your resume)
• The candidate must have practical research competence by the documented publication of scientific publications on several of the following areas: (i) design and modification of lignocellulosic materials, (ii) structural characterisation of soft matter using solid-state techniques, including microscopy, spectroscopy and scattering techniques, (iii) polysaccharide (bio)chemistry, and/or (iv) macromolecular/polymer science
• The candidate should have excellent communication in scientific English, both orally and written
• As a person, you should show independence to plan and perform your research experiments after discussion with the team, and excellent cooperation abilities with the researchers in the BioUPGRADE project and within the research group at KTH

Preferred qualifications

• Competence on the use of advanced methods for carbohydrate analysis, including mass spectrometry, is desirable
• Proof of (co)-supervision of doctoral, master and bachelor degree students is also desirable
• Awareness of diversity and equal treatment issues with a special focus on gender equality and sustainability is a merit

Great emphasis will be placed on personal competency

Trade union representatives

You will find contact information to trade union representatives at KTH's webbpage.

Application

Log into KTH's recruitment system in order to apply to this position. You are the main responsible to ensure that your application is complete according to the ad.

The application must include:

• CV including relevant professional experience and knowledge
• Copy of diplomas and grades from your previous university studies. Translations into English or Swedish if the original documents have not been issued in any of these languages
• Brief account of why you want to conduct research aligned to the BioUPGRADE vision, your academic interests and how they relate to your previous studies and future goals. Max two pages long
• Brief description of which approaches, methods and techniques would you use to characterise the surface modification of lignocellulose polymers. Max 1 page long
• By submitting this application, the candidate accepts that the candidacy may be evaluated by all members of the consortium.

Your complete application must be received at KTH no later than the last day of application, midnight CET/CEST (Central European Time/Central European Summer Time)

About the employment

The position offered is for, at the most, two years.

A position as a postdoctoral fellow is a time-limited qualified appointment focusing mainly on research, intended as a first career step after a dissertation.

Others

Striving towards gender equality, diversity & equal conditions is both a question of quality for KTH and a given part of our values.

For information about processing of personal data in the recruitment process please read here.

We firmly decline all contact with staffing, recruitment agencies & job ad salespersons.

Disclaimer: In case of discrepancy between the Swedish original and the English translation of the job announcement, the Swedish version takes precedence.

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Postdoc in Local Energy Studies (Social Science) M/V

 

Within the University of Twente the section of Governance and Technology for sustainability (CSTM) participates in the Digitalization of the Energy System (DES) research program of The Centre for Energy Innovation (CEI).

We are looking for a postdoc as researcher in number of interdisciplinary research projects. Our engineering colleagues study the technical possibilities for demand-side management and flexibility and the integration of (renewable) distributed energy sources in decentralized energy systems. Complementary you will study the governance, regulatory and economic factors that drive the changes in these systems. Additionally, you evaluate the societal impacts of the changes on consumers, producers, citizens, energy communities, government and the wider society.

This project requires a post doc who is proficient in writing and speaking Dutch and English. You need to be available on short notice, and a PhD in social-science such as in public administration, political science, planning, geography or economics is a strict condition.

The challenge

The systems you will study are on different geographical and government scales and in various countries. They range from housing blocks to regions. All these cases are on the edge of what is technically and societally taking place in the renewable energy transition.

In this position, you will:

• Help to develop a comprehensive framework of governance and regulatory conditions for local energy systems;
• Analyze the social acceptability of renewable energy choices;
• Design social innovations in these energy systems;
• Evaluate the impact of the social innovations on these systems.

YOUR PROFILE

• A highly motivated researcher with a PhD degree in a relevant social science, such as in public administration, political science, planning, geography, economics or related;
• You have a shown interest and/or experience in energy studies and affinity with renewable energy technology;
• Good team spirit, excellent organizational skills and a transdisciplinary attitude;
• Excellent communicative skills, both within academia and in relation to societal partners;
• You like to work in an internationally oriented environment;
• Proficiency in Dutch and English is a requirement.

OUR OFFER

• The UT provides a dynamic and international environment, combining the benefits of academic research with a topic of high industrial relevance, excellent working conditions, an exciting scientific environment and a green and lively campus;
• A postdoc position for a period of 2 years;
• Full status as an employee at the UT, including pension and health care benefits;
• Gross salary: ranging from € 3.353,- to € 4.402,- per month, plus holiday allowance (8%) and end-of-year bonus (8.3%);
• Excellent facilities for professional and personal development;
• Good secondary conditions, in accordance with the collective labour agreement CAO-NU for Dutch universities;
• A green campus with lots of sports facilities and an international scientific community.

INFORMATION AND APPLICATION

Please include an application/motivation letter, emphasizing your specific interest, qualifications and motivation to apply for this position, a detailed CV (resume) and a publication list. You can apply until 23 April 2021.

For more information please contact dr. F. Coenen, telephone (+31-(0)53-4893216, e-mail: f.h.j.m.coenen@utwente.nl.

ABOUT THE DEPARTMENT

The CSTM section is embedded in the department of Technology, Policy and Society (TPS), one of the four departments of the faculty Behavioral, Management and Social Science (BMS). Within this larger academic community there is a multifold of teaching and research activities offering opportunities.

The University of Twente (UT) is the only campus university in the Netherlands; divided over five faculties we provide more than fifty educational programmes. We have a strong focus on personal development and give hardworking researchers scope for carrying out groundbreaking research.

We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, or disability status. Because of our diversity values we do particularly support women to apply.

ABOUT THE ORGANIZATION

The Faculty of Behavioural, Management and Social sciences (BMS) aims to play a pivotal role in understanding, co-engineering and evaluating innovation in society. Innovation is driven by advances in technology. By means of 'social engineering', we are here to integrate these advances in society. As a people-first tech university, we align these advances with the needs and behaviour of humans. We ensure proper public and private management as well as robust, inclusive and fair organisational structures. The faculty of BMS does this by developing, transferring and applying high-quality knowledge of Psychology, Business Administration, Public Administration, Communication Science, Philosophy, Educational Science, and Health Sciences. Our research and education in these disciplines is challenge-based. The BMS research programmes are directly linked to our research institutes: Mesa+ Institute for Nanotechnology, the TechMed Centre and the Digital Society Institute.
As an employer, the BMS Faculty offers jobs that matter. We equip you as a staff member to shape new opportunities both for yourself and for our society. With our Faculty, you will be part of a leading tech university that is changing our world for the better. We offer an open, inclusive and entrepreneurial climate, in which we encourage you to make healthy choices, for example, with our flexible, customizable conditions.

University of Twente (UT)

University of Twente (UT) has entered the new decade with an ambitious, new vision, mission and strategy. As ‘the ultimate people-first university of technology' we are rapidly expanding on our High Tech Human Touch philosophy and the unique role it affords us in society. Everything we do is aimed at maximum impact on people, society and connections through the sustainable utilisation of science and technology. We want to contribute to the development of a fair, digital and sustainable society through our open, inclusive and entrepreneurial attitude. This attitude permeates everything we do and is present in every one of UT's departments and faculties. Building on our rich legacy in merging technical and social sciences, we focus on five distinguishing research domains: Improving healthcare by personalised technologies; Creating intelligent manufacturing systems; Shaping our world with smart materials; Engineering our digital society; and Engineering for a resilient world.

As an employer, University of Twente offers jobs that matter. We equip you as a staff member to shape new opportunities both for yourself and for our society. With us, you will be part of a leading tech university that is changing our world for the better. We offer an open, inclusive and entrepreneurial climate, in which we encourage you to make healthy choices, for example, with our flexible, customisable conditions.

POSTDOC IN LOCAL ENERGY STUDIES (SOCIAL SCIENCE) M/V

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Postdoc position in Mobile Security & Privacy

 

The Services and Cyber Security (SCS) group at the University of Twente, together with the Design and Analysis of Communication Systems (DACS) group, is looking for a postdoc to join the research team, working at the intersection between mobile security and privacy, machine learning, and web measurement. The successful candidate will be involved in a collaboration with the University of Toronto and the Hospital for Sick Children in Canada. The project is an investigation into data sharing practices, privacy leaks, and targeted advertisements in mobile health apps for children. Mobile apps routinely transmit user (health) data to third parties and commercial entities to improve the user experience or monetize the app through targeted ads. It is therefore critical to characterize the data sharing practices of child health apps and examine the advertising impact of transmitted data. Within this project, you will:

• Perform research activity in the design and development of novel tools to detect privacy leaks in Android and iOS apps and evaluate data sharing practices of a large corpus of mobile apps.
• Perform web scans and conduct a systematic content analysis of targeted advertising presented to children within apps, as well as apply machine learning techniques to characterize ad content.
• Participate in the supervision of research students working on related projects.
• Collaborate with health experts and social scientists involved in the project.

You will work closely with Dr. Andrea Continella from the Services and Cyber Security (SCS) group (https://utwente.nl/scs) and Dr. Ralph Holz from the Design and Analysis of Communication Systems (DACS) group (https://utwente.nl/dacs).

YOUR PROFILE

• A highly motivated, positive and a hardworking researcher, aspiring to do world-class research and having real-world impact;
• A PhD degree with an excellent publication record in computer science or a related field; applications from candidates who are about to complete their PhD degree will be considered as well;
• Specialized in the domain of cybersecurity and a strong background in networks and system security; a solid background in mobile security, machine learning, and Internet-wide measurements are of additional advantage;
• An independent and original thinker with a creative mindset and excellent analytical and communication skills;
• Proficiency in English (at least C1 in CEFR or 3+ in ILR).

OUR OFFER

The terms of employment are in accordance with the Dutch Collective Labour Agreement for Universities (CAO) and include:

• A fulltime postdoc position for 12 months. Starting date will be in consultation;
• Full status as an employee at the UT, including pension and health care benefits;
• Gross salary from € 3.353 per month depending on experience and qualifications, plus holiday allowance (8%) and end-of-year bonus (8.3%);
• Excellent facilities for professional and personal development.

INFORMATION AND APPLICATION

Are you interested in joining our team? Please submit your application before 10 April 2021 via the “Apply now” button below, and include:

• A detailed CV (resume), containing your publications list and contact details of 3 referees.
• An academic transcript of Ph.D. education (if not available yet, provide an academic transcript of M.Sc. and information regarding the expected graduation date).
• A motivation letter, emphasizing your specific interest and motivation to apply for this position.

You are welcome to contact Dr. Andrea Continella (a.continella@utwente.nl) for any questions you might have.

ABOUT THE ORGANIZATION

The faculty of Electrical Engineering, Mathematics and Computer Science (EEMCS) uses mathematics, electronics and computer technology to contribute to the development of Information and Communication Technology (ICT). With ICT present in almost every device and product we use nowadays, we embrace our role as contributors to a broad range of societal activities and as pioneers of tomorrow's digital society. As part of a people-first tech university that aims to shape society, individuals and connections, our faculty works together intensively with industrial partners and researchers in the Netherlands and abroad, and conducts extensive research for external commissioning parties and funders. Our research has a high profile both in the Netherlands and internationally. It has been accommodated in three multidisciplinary UT research institutes: Mesa+ Institute, TechMed Centre and Digital Society Institute.

As an employer, the EEMCS Faculty offers jobs that matter. We equip you as a staff member to shape new opportunities both for yourself and for our society. With our Faculty, you will be part of a leading tech university that is changing our world for the better. We offer an open, inclusive and entrepreneurial climate, in which we encourage you to make healthy choices, for example, with our flexible, customizable conditions.

University of Twente (UT)

University of Twente (UT) has entered the new decade with an ambitious, new vision, mission and strategy. As ‘the ultimate people-first university of technology' we are rapidly expanding on our High Tech Human Touch philosophy and the unique role it affords us in society. Everything we do is aimed at maximum impact on people, society and connections through the sustainable utilisation of science and technology. We want to contribute to the development of a fair, digital and sustainable society through our open, inclusive and entrepreneurial attitude. This attitude permeates everything we do and is present in every one of UT's departments and faculties. Building on our rich legacy in merging technical and social sciences, we focus on five distinguishing research domains: Improving healthcare by personalised technologies; Creating intelligent manufacturing systems; Shaping our world with smart materials; Engineering our digital society; and Engineering for a resilient world.

As an employer, University of Twente offers jobs that matter. We equip you as a staff member to shape new opportunities both for yourself and for our society. With us, you will be part of a leading tech university that is changing our world for the better. We offer an open, inclusive and entrepreneurial climate, in which we encourage you to make healthy choices, for example, with our flexible, customisable conditions.

POSTDOC POSITION IN MOBILE SECURITY & PRIVACY

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Postdoctoral researcher "Miniaturized magnetic resonance flow probe

 

The aim of this project, which will be carried out in collaboration with TU Delft and several companies, is to develop a miniaturized magnetic resonance system, completed with integrated electronics for stabilization, excitation and detection. The system will be used to measure the flow rate of multiphase systems in the micro to milli liter per minute range. The project builds on the knowledge of a recently finished PhD project "Permanent magnet systems for microfluidic applications" and will deal specifically with the construction of the magnetic part of the sensor. The work will include system modelling by numerical means, design, assembly, and testing.

See: https://research.utwente.nl/en/publications/permanent-magnet-systems-for-microfluidic-applications

YOUR PROFILE

You have obtained a MSc or PhD degree in (Applied) Physics, Electrical Engineering, or a closely related discipline. You have a high level of knowledge of magnetic fields and practical experience with magnetic systems. Previous experience with magnetic resonance (NMR or MRI) instrumentation is preferred.

You have an ability to both work independently and as a member of a research team. Excellent analysis skills and an analytical mind-set, as well as excellent communication skills, including written, are desired. English language proficiency is a must.

OUR OFFER

The University of Twente offers a stimulating work environment in an area of applied, forefront research. You will have an employment contract for the duration of 1 year and can participate in all employee benefits that the UT offers. The gross monthly salary depends on your level of experience, current salary scales and employment conditions can be found at https://www.utwente.nl/en/hr/terms-of-employment/.

The offer further involves: a holiday allowance of 8% of the gross annual salary and a year-end bonus of 8.3%, a solid pension scheme, a minimum of 29 holidays, and numerous professional and personal development programmes.

INFORMATION AND APPLICATION

Your reaction should include an application/motivation letter, emphasizing your specific interest and motivation, a detailed CV, and an academic transcript of B.Sc. and M.Sc. education. An interview and a scientific presentation will be part of the selection procedure. Please apply via the provided button below.

 

For further information you can contact Han Gardeniers (j.g.e.gardeniers@utwente.nl).

ABOUT THE DEPARTMENT

The research of the Mesoscale Chemical Systems (MCS) chair, headed by Han Gardeniers, originates from the group's unique expertise in micro and nanofabrication, backed by the outstanding experimental facilities of MESA+ NanoLab.

Focal points in the research are:

The development of 3D nanostructures for solar to electricity to chemical conversion
Microreactors as a means of chemical process intensification (sonochemistry, high pressure, electricity-driven)
Miniaturized analytical tools and MEMS-based sensors for a variety of application fields (forensics, health, environment, chemical process control)
Microfluidic systems for life science applications (e.g. drug delivery)

ABOUT THE ORGANIZATION

TNW Faculty (Faculty of Science & Technology)

The Faculty of Science & Technology (Technische Natuurwetenschappen, TNW) engages some 700 staff members and 2000 students in education and research on the cutting edge of chemical technology, applied physics and biomedical technology. Our fields of application include sustainable energy, process technology and materials science, nanotechnology and technical medicine. As part of a people-first tech university that aims to shape society, individuals and connections, our faculty works together intensively with industrial partners and researchers in the Netherlands and abroad, and conducts extensive research for external commissioning parties and funders. Our research has a high profile both in the Netherlands and internationally and is strengthened by the many young researchers working on innovative projects with as doctoral candidates and post-docs. It has been accommodated in three multidisciplinary UT research institutes: Mesa+ Institute, TechMed Centre and Digital Society Institute.

As an employer, the TNW Faculty offers jobs that matter. We equip you as a staff member to shape new opportunities both for yourself and for our society. With our Faculty, you will be part of a leading tech university that is changing our world for the better. We offer an open, inclusive and entrepreneurial climate, in which we encourage you to make healthy choices, for example, with our flexible, customisable conditions.

University of Twente (UT)

University of Twente (UT) has entered the new decade with an ambitious, new vision, mission and strategy. As ‘the ultimate people-first university of technology' we are rapidly expanding on our High Tech Human Touch philosophy and the unique role it affords us in society. Everything we do is aimed at maximum impact on people, society and connections through the sustainable utilisation of science and technology. We want to contribute to the development of a fair, digital and sustainable society through our open, inclusive and entrepreneurial attitude. This attitude permeates everything we do and is present in every one of UT's departments and faculties. Building on our rich legacy in merging technical and social sciences, we focus on five distinguishing research domains: Improving healthcare by personalised technologies; Creating intelligent manufacturing systems; Shaping our world with smart materials; Engineering our digital society; and Engineering for a resilient world.

As an employer, University of Twente offers jobs that matter. We equip you as a staff member to shape new opportunities both for yourself and for our society. With us, you will be part of a leading tech university that is changing our world for the better. We offer an open, inclusive and entrepreneurial climate, in which we encourage you to make healthy choices, for example, with our flexible, customisable conditions.

POSTDOCTORAL RESEARCHER "MINIATURIZED MAGNETIC RESONANCE FLOW PROBE"

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POSTDOC­TORAL RE­SEARCHER IN NEUROSCIENCE, PAR­TIC­U­LARLY SYS­TEM NEUROSCIENCE AND NEURO-IM­MUN­O­LOGY

 

The Biology of Neuro-Immune Interaction Laboratory at the HiLIFE-Neuroscience Center, University of Helsinki, is led by P.I. Dr. Francesco M. Noé . We are now seeking a postdoctoral fellow to join our lab.

The position is a full-time primary research fellowship for a postdoctoral scholar interested in pursuing a career in neuroscience, particularly in system neuroscience and in neuro-immunology. Postdoctoral fellow will be expected to develop original research projects focused on understanding the biological determinants of brain activity in physiological and pathological conditions, with specific focus on traumatic brain injury and epilepsy. Our current projects include understanding the role of neuro-immunity in the development of neurodegenerative diseases, and of CNS lymphatic system in brain functions.

The fellow will work on animal models of diseases and will have the possibility to use advanced investigation tools for in vivo neuroimaging (multiphoton and focused ultrasound), electroencephalography and behavioral, as well as flow cytometry and molecular biology. Postdoctoral fellow will be involved in all the aspects of data collection and analyses, and is expected to disseminate research findings via peer-reviewed manuscripts and scientific presentations at national and international conferences. S/he will be also involved in the supervision of PhD students, grant writing and in collaborative projects both in Finland and abroad.

Who we are looking for: To add relevant expertise to our lab, we are seeking a highly motivated neuroscientist with an interest to work in a multidisciplinary and challenging environment. The successful candidate must have a PhD or MD, and experience with neuroimaging, EEG and/or flow cytometry. Previous experience in RNAseq data analysis, R, and Matlab or Python software is a plus. The candidate should also have a strong publication record, as well as project management skills, critical and analytical thinking, and social and communication skills. Fluent spoken and written English is a requirement.

The position is filled for a fixed term of one year, with the possibility to renew it, starting from April 2021 or as agreed. The salary of the position is determined in accordance with the salary system of Finnish universities. The University of Helsinki offers comprehensive services to its employees, including occupational health care and health insurance, sports facilities, and opportunities for professional development. A trial period of 6 months will be applied.

For further information on the position, please contact: Academy Fellow Francesco M. Noè, francesco.noe@helsinki.fi

How to Apply: Please submit your application via the University of Helsinki Recruitment System by clicking the ‘Apply for the position button’ below. Internal applicants (i.e. current employees of the University of Helsinki) should submit their applications through the SAP HR portal. If you need support with the recruitment system, please contact recruitment@helsinki.fi.

Application should contain the following appendices:

• detailed CV (max. 3 pages)
• motivation letter detailing research interest, experience, and career goals
• academic merits and research activities (max 1 page)
• three letters of recommendation (ideally including the applicant’s actual PhD supervisor)

Applications will be accepted until 30.05.2021 and revised until the position is filled.

The University of Helsinki is an equal opportunity employer. International applicants are encouraged.

HiLIFE -Neuroscience Center

The Neuroscience Center is an international research unit within Helsinki Institute of Life Science (HiLIFE) of the University of Helsinki, a leading Nordic university with a strong commitment to life science research. The research focus of NC is on translational brain plasticity. We carry out research relevant for the human brain both in health and disease, and during development and aging, by applying versatile approaches and modern technology platforms. NC aims at making fundamental discoveries about brain functions and especially translate research findings into improvements in the treatment, prevention and diagnosis of psychiatric and neurological disorders. The research in NC spans across several scales from stem cell research and molecular neuroscience to systems and cognitive neuroscience in both animal and human models. The research groups of NC conduct research in neuroscience at the highest international level and actively apply the results for the benefit of the society. NC collaborates actively with other units of HiLIFE and faculties of the University of Helsinki, Helsinki University Central Hospital, and Neurocenter Finland.

Helsinki Institute of Life Science

Helsinki Institute of Life Science (HiLIFE) is a new institute established in 2017 that supports high quality life science research across the University campuses and faculties. HiLIFE builds on existing strengths and new recruits and partnerships to create an attractive international environment for researchers to solve grand challenges in health, food, and environment. HiLIFE coordinates research infrastructures in life sciences and provides research-based interdisciplinary training.

University of Helsinki

The University of Helsinki (UH), founded in 1640, is a vibrant scientific community of 40,000 students and researchers. It is one of the leading multidisciplinary research universities and ranks among the top 100 international universities in the world. It is currently investing heavily in life sciences research. UH offers comprehensive services to its employees, including occupational health care and health insurance, sports facilities, and opportunities for professional development.

Due date

30.05.2021 23:59 EEST

Apply for the position

POST-DOC­TORAL RE­SEARCH­ERS AND/​OR PHD-STU­DENTS IN CELL AND STRUC­TURAL BIOLOGY

 

The HiLIFE - Institute of Biotechnology (BI), located in the Viikki science park, is a research institute at University of Helsinki, The institute harbors ~35 research groups and 250 researchers, and it operates at the highest international level. For more information on the Institute, please visit https://www.helsinki.fi/en/hilife-institute-of-biotechnology.

The ‘Actin-based molecular machines’ group of Academy Professor Pekka Lappalainen is inviting applications for post-doctoral researchers and/or PhD-students in cell biology, biochemistry, and structural biology.

The actin cytoskeleton is critical for a vast number of vital cellular processes such as morphogenesis, motility, endocytosis, cytokinesis, and mechanosensing. Abnormalities in actin-dependent processes, including cell morphogenesis, motility and cytokinesis, are hallmarks of cancer. Moreover, many pathogens exploit the actin polymerization machinery of the host cell during the infection process. The research group of Pekka Lappalainen uses an array of biochemical, cell biological, genetic, and structural biology methods to reveal how structure and dynamics of the actin cytoskeleton are regulated in various cellular and pathological processes.

The group is seeking for dedicated and enthusiastic post-doctoral fellows and/or PhD-students to join projects that focus on: 1). Understanding the mechanisms by which contractile, mechanosensitive actomyosin bundles assemble in human cells, and 2). Elucidating functions of the actin cytoskeletons in evolutionarily distant pathogenic unicellular parasites. The post-doctoral applicants should hold PhD in cell biology, biochemistry, or a related field. Strong expertise in protein biochemistry, structural biology, or cell biology is highly beneficial. The PhD-student applicants should obtain MSc or related degree in the molecular biology field latest by the end of year 2021, and have a strong interest to carry out cutting-edge research. The PhD-student will be subsequently enrolled in one of the graduate programs of our university. The positions will provide multiple opportunities for collaborations and laboratory visits abroad. An attitude to carry out ambitious research projects, as well as to learn and apply a wide variety of methodologies and advanced techniques is highly appreciated. The working language of the laboratory is English; knowledge of the Finnish language is not necessary.

The postdoctoral researcher and PhD-student positions are initially limited to 2 and 4 years, respectively, with a possibility of extension. A trial period of 6 months will be applied, and the salaries will be based on the University salary scheme for teaching and research personnel composed of both task specific and personal performance components.

Application should include the following documents as a single pdf file (max 5 pages): CV, list of publications, motivation letter including a description of your research interests, and the names and telephone numbers of at least two referees. Please submit your application, together with the required pdf attachment, through the University of Helsinki electronic recruitment system by clicking on the ‘Apply for job’ button. Internal applicants (i.e., current employees of the University of Helsinki) should submit their applications through the SAP HR portal. For technical support regarding the recruitment system, please contact ‘rekrytointi@helsinki.fi’.

The deadline for the applications is 15th of April, 2021, but the positions will be filled immediately once suitable candidates have been identified.

For informal inquiries, contact ‘pekka.lappalainen(at)helsinki.fi’, and for more information about our research, please visit https://www.helsinki.fi/en/researchgroups/actin-based-molecular-machines

For technical support regarding the recruitment system, please contact rekrytointi@helsinki.fi.

Selected recent publications:
Hakala M, Wioland H, Tolonen M, Kotila T, Jegou A, Romet-Lemonne G, Lappalainen P (2021): Twinfilin uncaps filament barbed ends to promote turnover of lamellipodial actin networks. Nature Cell. Biol. 23: 147-159.
Lehtimäki JI, Rajakylä EK, Tojkander S, Lappalainen P (2021): Generation of stress fibers through myosin-driven re-organization of the actin cortex. eLife. 10:e60710.
Kumari R, Jiu Y, Carman PJ, Tojkander S. Kogan K, Varjosalo M, Gunning PW, Dominguez R, Lappalainen P (2020): Tropomodulins control the balance between protrusive and contractile structures by stabilizing actin-tropomyosin filaments. Curr. Biol. 30: 767–778.
Kotila T, Wioland H, Enkavi G, Kogan K, Vattulainen I, Jégou A, Romet-Lemonne G, Lappalainen P (2019): Mechanism of synergistic actin filament pointed end depolymerization by cyclase-associated protein and cofilin. Nature Commun. 10:5320.
Jiu Y, Kumari R, Fenix AM, Schaible N, Liu X, Varjosalo M, Krishnan R, Burnette DT, Lappalainen P (2019): Myosin-18B promotes the assembly of myosin II stacks for maturation of contractile actomyosin bundles. Curr. Biol. 29:81-92.

Finland is a member of the EU, has high quality free schooling (also in English), generous family benefits and healthcare, and was recently ranked as the best country in the world for expat families and in the world’s top ten most livable cities. Finland and the Helsinki region possess top expertise in sciences in terms of a vibrant talent pool, leading research, strong support services and functioning collaboration networks. For more information about working at the University of Helsinki and living in Finland, please see helsinki.fi/en/university/working-at-the-university.

Helsinki Institute of Life Science (HiLIFE) is a new institute established in 2017 that supports high quality life science research across the University campuses and faculties. HiLIFE builds on existing strengths and new recruits and partnerships to create an attractive international environment for researchers to solve grand challenges in health, food, and environment. HiLIFE coordinates research infrastructures in life sciences and provides research-based interdisciplinary training.

The University of Helsinki, founded in 1640, is one of the world’s leading universities for multidisciplinary research. The university has an international academic community of 40,000 students and staff members. The University of Helsinki offers comprehensive services to its employees, including occupational health care and health insurance, sports facilities, and professional development opportunities. The International Staff Services office assists employees from abroad with their transition to work and life in Finland.

Due date

15.04.2021 23:59 EEST

Apply for the position

POSTDOC­TORAL RE­SEARCHER IN MO­LECU­LAR BIOLOGY OR BIOIN­FORM­AT­ICS

 

Laboratory of Docent Daniela Ungureanu and Professor Jussi Taipale at the Medical Systems Biology group (https://www2.helsinki.fi/en/researchgroups/medical-systems-biology ) at the Applied Tumour Genetic Program at University of Helsinki, Faculty of Medicine invites applications for the position of

POSTDOCTORAL RESEARCHER

Our research group is part of the Academy of Finland's Center of Excellence in Tumour Genetics Research. The laboratory focuses on the study of transcriptional control of cell growth, using functional genomics and systems biology. Current lines of work include high-throughput determination of binding sites and binding specificities of human transcription factors, using this information to identify regulatory elements that control cell growth during normal development or in cancer. We are also working on pharmaco-genomic studies of drug resistance mechanisms in cancers such as ovarian cancer.

Applicants with a doctoral degree and strong background in molecular biology/bioinformatics who are interested in working in an inter-disciplinary environment are particularly encouraged to apply. Applicant must be able to work independently and have good communication skills in English.

The appointment will be for 3 years starting upon agreement. Trial period of 6 months will be applied. The monthly gross salary will be appr. 3200-3500 € per month depending on the appointee’s qualifications and experience. In addition, University of Helsinki offers comprehensive services to its employees, including occupational health care and opportunities for professional development. Further information at www.helsinki.fi/en/about-us/careers.

For additional information about the position, please contact Dr. Daniela Ungureanu: daniela.ungureanu (at) helsinki.fi. For additional information about the application process, please contact HR Specialist Päivi Sinisalo: paivi.sinisalo (at) helsinki.fi.

Please submit your application as a single PDF file containing your CV, publication list including impact factors and two letters of reference through the University’s electronic recruitment system by clicking “Apply for the position” link below. Internal applicants (i.e., current employees of the University of Helsinki) must submit their applications through the SAP HR portal, under the tab “Career and Job”. If you have questions about the recruitment system, please contact rekrytointi (at) helsinki.fi.

The deadline for applications is 30 April 2021.

Selected publications from Taipale lab:

Zhu et al. The interaction landscape between transcription factors and the nucleosome. Nature. 2018, Oct, 76-81.

Yin et al. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science, 2017, May 5;356(6337).

Nitta et al. Conservation of transcription factor binding specificities across 600 million years of bilateria evolution. Elife. 2015 Mar 17;4.

Turunen et al. (2014) Uterine Leiomyoma-Linked MED12 Mutations Disrupt Mediator-Associated CDK Activity. Cell Rep 7, 654–60.

Yan et al. (2013) Transcription factor binding in human cells occurs in dense clusters formed around cohesin anchor sites. Cell 154, 801-13.

The Faculty of Medicine promotes high quality scientific research. It provides research-based undergraduate and postgraduate education in medicine, dentistry, psychology and logopedics, and an international Master's Programme in Translational Medicine. It also offers psychotherapist education. In addition to its teaching and research activities, the Faculty serves as a significant expert organisation in the healthcare sector and contributes to the discourse on ethics in the field. The Faculty aims to be one of the best medical research faculties in the world, while reinforcing its status as a distinguished institution of medical education.

The Faculty of Medicine at the University of Helsinki constitutes the academic medical centre together with HUS Helsinki University Hospital and the Helsinki Institute of Life Science (HiLIFE). This medical centre has been successful in international comparisons, ranking among the top 10 medical campuses in Europe and the top 50 globally.

Due date

30.04.2021 23:59 EEST

Apply for the position

POST DOCTORAL RESEARCHER IN STRUCTURAL BIOLOGY

 

The laboratory of Dr. Tommi Kajander at the Institute of Biotechnology, HiLIFE, University of Helsinki, Finland, is inviting applications for post-doctoral researcher in the area of protein biochemistry and structural biology in a joint project with Prof. Mart Saarma’s laboratory. We are seeking for dedicated and enthusiastic scientist to work on the structure and function of novel endoplasmic reticulum effector protein-receptor interactions in ER stress response regulation. Main targets are CDNF and MANF proteins and their interaction complexes in the ER.

The Institute of Biotechnology is a research institute at University of Helsinki, located in the Viikki science park. The institute harbors ~35 research groups and 250 researchers, and it operates at the highest international level. For more information on the Institute, please visit https://www.helsinki.fi/en/hilife-institute-of-biotechnology.
The institute has excellent infrastructure for structural biology (X-ray, CryoEM, NMR) including the crystallography core facility run by the PI.

The post-doctoral applicants should hold PhD in biochemistry or a related field. Strong experience in protein biochemistry including cloning and mutagenesis and protein expression and purification, from various hosts and good communication skills in English are required. Knowledge and experience in structural biology and molecular biophysics techiques and cell culture is beneficial. This is an opportunity to work on high impact targets and obtain in depth technical skills in the research area. The position will provide excellent opportunities for collaborations, as this is a joint project in close collaboration with Prof. Mart Saarma’s group, with also potential international and national collaborations and visits to e.g. synchrotron sources in Europe (ESRF, DLS, MAXIV). An attitude to carry out ambitious research projects, good problem solving skills, goal-oriented mind-set and willingness to learn and apply new methodologies is highly appreciated. The working language of the laboratory is English; knowledge of Finnish is not a requirement.

The postdoctoral position is initially limited to 1 year, with a possibility of extension to three years. Trial period of 6 months will be applied. The salaries will be based on the University salary scheme (level 5) for teaching and research personnel composed of both task specific and personal performance component The position is available immediately or as agreed.

Application should include the following documents as a single pdf file (max 5 pages): CV (max 2 pages), list of publications, motivation letter (max 1 page) including a description of your research interests, and the names and contact details of at least two referees. Please submit your application, together with the required pdf attachment, through the University of Helsinki electronic recruitment system by clicking on the ‘Apply for job’ button. Internal applicants (i.e., current employees of the University of Helsinki) should submit their applications through the SAP HR portal. For technical support regarding the recruitment system, please contact ‘rekrytointi@helsinki.fi’.

The deadline for the applications is 31st of May, 2021, but the position will be filled immediately once suitable candidates have been identified.

For informal inquiries, contact ‘tommi.kajander(at)helsinki.fi’
See also:
https://www2.helsinki.fi/en/researchgroups/structural-biology-of-protein...
https://www2.helsinki.fi/en/researchgroups/neurotrophic-factors-and-rege...

For technical support regarding the recruitment system, please contact rekrytointi@helsinki.fi.

Selected recent references related to project and the laboratory:
Kovaleva V, Yu LY, Ivanova L, Nam J, Eesmaa A, Kumpula EP, Huiskonen J, Lindholm P, Voutilainen M, Karelson M, Saarma M. MANF regulates unfolded protein response and neuronal survival through its ER-located receptor IRE1α bioRxiv 2020.09.22.307744

Eesmaa A, Yu LY, Göös H, Nõges K, Kovaleva V, Hellman M, Zimmermann R, Jung M, Permi P, Varjosalo M, Lindholm P, Saarma M. The cytoprotective protein MANF promotes neuronal survival independently from its role as a GRP78 cofactor. J Biol Chem. 2021 Jan 15;296:100295.

Lindahl M, Saarma M, Lindholm P. Unconventional neurotrophic factors CDNF and MANF: Structure, physiological functions and therapeutic potential. Neurobiol Dis. 2017 Jan;97(Pt B):90-102.

Lindholm, P., Voutilainen, M .H., Laurén, J., et al. and Saarma, M. (2007) Novel neurotrophic factor CDNF protects and rescues midbrain dopamine neurons in vivo. Nature, 448, 73-77.

Karki S, Shkumatov AV, Bae S, Kim H, Ko J, Kajander T. Structural basis of SALM3 dimerization and synaptic adhesion complex formation with PTPσ. Sci Rep. 2020 Jul 14;10(1):11557.

Paatero A, Rosti K, Shkumatov AV, Sele C, Brunello C, Kysenius K, Singha P, Jokinen V, Huttunen H, Kajander T. Crystal Structure of an Engineered LRRTM2 Synaptic Adhesion Molecule and a Model for Neurexin Binding. Biochemistry. 2016 Feb 16;55(6):914-26

Finland is a member of the EU, has high quality free schooling (also in English), generous family benefits and healthcare, and was recently ranked as the best country in the world for expat families and in the world’s top ten most livable cities. Finland and the Helsinki region possess top expertise in sciences in terms of a vibrant talent pool, leading research, strong support services and functioning collaboration networks. For more information about working at the University of Helsinki and living in Finland, please see helsinki.fi/en/university/working-at-the-university.

Helsinki Institute of Life Science (HiLIFE) is a new institute established in 2017 that supports high quality life science research across the University campuses and faculties. HiLIFE builds on existing strengths and new recruits and partnerships to create an attractive international environment for researchers to solve grand challenges in health, food, and environment. HiLIFE coordinates research infrastructures in life sciences and provides research-based interdisciplinary training.

The University of Helsinki, founded in 1640, is one of the world’s leading universities for multidisciplinary research. The university has an international academic community of 40,000 students and staff members. The University of Helsinki offers comprehensive services to its employees, including occupational health care and health insurance, sports facilities, and professional development opportunities. The International Staff Services office assists employees from abroad with their transition to work and life in Finland.

Due date

31.05.2021 23:59 EEST

Apply for the position

TWO POSTDOCS IN EPI­DEMI­OLOGY / STAT­IST­ICS / HU­MAN GE­NET­ICS

 

The Institute for Molecular Medicine Finland (FIMM) is an international research institute focusing on human genomics and personalised medicine at the University of Helsinki. In the beginning of 2017 FIMM joined the University of Helsinki’s new life science research centre, Helsinki Institute of Life Science HiLIFE, as an operational unit. FIMM integrates molecular medicine research, technology centre and biobanking infrastructures under one roof, promoting translational research in grand challenge projects, specifically, the impact of genome information from the Finnish population in personalised health and medicine, individualised cancer medicine, and digital molecular medicine. FIMM is part of the Nordic EMBL Partnership for Molecular Medicine, composed of the European Molecular Biology Laboratory (EMBL) and the centres for molecular medicine in Norway, Sweden and Denmark, and the EU-LIFE Community.

The INTERVENE consortium (https://www.interveneproject.eu/) is a 5-year 10 million € EU funded project that aims to develop and test next generation tools for disease prevention, diagnosis and personalized treatment utilizing the first US-European pool of genomic and health data and integrating longitudinal and disease-relevant -omics data into genetic risk scores. The consortium includes 18 closely collaborating partners from 11 countries.

The coordinating center at the Institute for Molecular Medicine Finland (FIMM), University of Helsinki is looking for two excellent and motivated postdoctoral researchers to join INTERVENE under the supervision of Prof. Samuli Ripatti and Dr. Andrea Ganna. Both positions are fully funded for 2-3 years with an additional possibility of extension. We offer stimulating work in a collegial and highly international environment with an unprecedented amount of health and genetic information from up to 1.7 million individuals.

About our research:
Professor Samuli Ripatti (https://www2.helsinki.fi/en/researchgroups/complex-disease-genetics) is the vice-director at FIMM, Professor of Biometry at Faculty of Medicine and a director of Academy of Finland’s Center of Excellence in Complex Disease Genetics. He is also affiliated with Broad institute of MIT and Harvard, MA, US. His research group has made seminal discoveries in understanding the link between genetic variation and risk factors for cardiometabolic diseases and common cancers. The Ripatti group also builds statistical and computational models for complex disease risk estimation and has played key roles in major Finnish sequencing and genotyping efforts, including FinnGen.

Dr. Andrea Ganna (https://www.dsgelab.org/) is an EMBL-group leader at FIMM and an instructor at Harvard Medical School and Massachusetts General Hospital. His research vision is to integrate genetic data and information from electronic health record/national health registries to enhance early detection of common diseases and public health interventions. Dr. Ganna has been recently awarded with an ERC starting grant to study the application of artificial intelligence methods for prediction of cardiovascular diseases.

Job description and qualifications:
The first INTERVENE postdoc will coordinate a multinational breast cancer clinical pilot study on translating genetic information to stratified treatment and screening. Preferably, candidates should have a background in clinical or medical genetics, or epidemiology/public health with statistics/data science/epidemiological skill set and an interest in developing tools to help clinicians make genetically informed decisions in their choices for treatment and cancer screening.

The second INTERVENE postdoc will work on the development and application of next generation risk prediction tools and pilot cutting edge approaches for disease prevention, diagnosis, and personalized treatment. We are primarily looking for candidates with a background in statistics, machine learning or related data science. The ideal candidate would also have experience in genetic prediction methods (e.g. polygenic risk scores) from genome-wide association studies and sequencing data.

The candidates should hold an M.D. degree and/or a Ph.D. or be about to finish the doctorate studies in the field of genetics, statistics, mathematics, computational sciences, (genetic) epidemiology or clinical medicine. We value scientific independence, publishing experience, and an aptitude towards developing and applying novel techniques. Together with the PI, candidates will be jointly responsible for coordinating projects and for supervising PhD students. Candidates will have the possibility to visit other INTERVENE partners for research purposes.

Contract & salary: Both positions are for a fixed term of 2-3 years with a possibility of extension. The salary of the position is determined in accordance with the salary system of Finnish universities and depends on the candidate’s qualifications. The University of Helsinki offers comprehensive services to its employees, including occupational health care and health insurance, sports facilities, and opportunities for professional development. A trial period of 6 months will be applied.

How to apply: The application should include cover letter, CV, list of publications, contact information for referees. Documents should be submitted as a single PDF file.

To apply, please submit the application through the University of Helsinki electronic recruitment system by clicking on the "Apply for job" link below. Internal applicants (i.e., current employees of the University of Helsinki) please submit your applications through the SAP HR portal. Please apply no later than May 16th, 2021.

For further information about the position, please contact the recruiting PIs: Prof. Samuli Ripatti samuli.ripatti@helsinki.fi); Dr. Andrea Ganna (aganna@broadinstitute.org)

If you need support with the recruitment system, please contact recruitment@helsinki.fi.

Helsinki Institute of Life Science
Helsinki Institute of Life Science (HiLIFE) is a new institute established in 2017 that supports high quality life science research across the University campuses and faculties. HiLIFE builds on existing strengths and new recruits and partnerships to create an attractive international environment for researchers to solve grand challenges in health, food, and environment. HiLIFE coordinates research infrastructures in life sciences and provides research-based interdisciplinary training.

University of Helsinki
The University of Helsinki (UH), founded in 1640, is a vibrant scientific community of 40,000 students and researchers. It is one of the leading multidisciplinary research universities and ranks among the top 100 international universities in the world. It is currently investing heavily in life sciences research. UH offers comprehensive services to its employees, including occupational health care and health insurance, sports facilities, and opportunities for professional development.

Due date

16.05.2021 23:59 EEST

Apply for the position