PhD position plant genetics, molecular and cellular physiology on stomatal function

 Do you want to participate in a world-renowned team in genetics and horticulture science as a PhD researcher at Wageningen University? Are you a connecting person who collaborates with researchers and breeders on innovative solutions in an ambitious research program?

Our research aims at understanding how plants respond to changes in abiotic conditions affecting plant product quality. Following measures to mitigate climate change growers have adopted alternative growth strategies, which might not be optimal for existing current cultivars.

An intriguing scientific and practical problem in modern horticulture relates to plants grown at high humidity, a consequence of closing windows in greenhouses to reduce energy loss. In leaves of such plants stomatal guard cells frequently become unresponsive to external cues and fail to close when appropriate. This phenomenon is referred to as stomatal malfunction and leads to reduced postharvest keeping quality due to increased water loss. However, the mechanisms leading to stomatal malfunction and the genetic variation causal for intraspecific differences in tolerance towards high humidity are unknown.

In this project we will make use of the model plant Arabidopsis thaliana and the ornamental species Chrysanthemum to identify the mechanism and genetic variation causal for stomatal malfunction after long exposure to high humidity. For this, we will make use of a combination of high throughput phenotyping, physiological measurements, genetic mapping, and genomic analyses.

The project is a collaboration between the Plant Science Groups ‘Horticulture and Product Physiology’ and ‘Genetics’, and industry partners for which we will hire two PhD students and a technician. This vacancy is targeted at applicants for the PhD position at the Laboratory of Genetics, focusing on the molecular, cellular, and physiological aspects of stomatal malfunctioning in the reference plant Arabidopsis.

We ask

• A successfully completed MSc degree in Genetics or Molecular Plant Physiology, Plant Biotechnology, or related
• Affinity with data driven investigation such as genomic and bioinformatic analyses;
• Intellectually curious, productive, and enjoys working in a committed and diverse team;
• You are a result-driven team player with creative ideas,
• You work very accurate and have organizational skills
• You have good communication and proficiency in English (a minimum of CEFR C1 level). For more information about this proficiency level, please visit our special language page: https://www.wur.nl/en/Education-Programmes/PhD-Programme/English-language-requirements.htm;

• you meet all the entry requirements of the  WUR PhD programme.

We offer

Wageningen University & Research offers excellent 

terms of employment. A few highlights from our  Collective Labour Agreement include:

• study leave and partially paid parental leave;
• working hours that can be discussed and arranged so that they allow for the best possible work-life balance;
• the option to accrue additional compensation / holiday hours by working more, up to 40 hours per week;
• there is a strong focus on vitality and you can make use of the sports facilities available on campus for a small fee;
• a fixed December bonus of 8.3%;
• excellent pension scheme.

In addition to these first-rate employee benefits, you will receive a fully funded PhD position and you will be offered a course program tailored to your needs and the research team.
The gross salary for the first year is € 2.541,- per month rising to € 3.247,- in the fourth year in according to the Collective Labour Agreements for Dutch Universities (CAO-NU) (scale P). This is based on a full-time working week of 38 hours. We offer a temporary contract for 18 months which will be extended for the duration of the project if you perform well.

There are plenty of options for personal initiative in a learning environment, and we provide excellent training opportunities. We are offering a unique position in an international environment with a pleasant and open working atmosphere.

You are going to work at the greenest and most innovative campus in Holland, and at a university that has been chosen as the “ Best University ” in the Netherlands for the 17th consecutive time.

Coming from abroad
Wageningen University & Research is the university and research centre for life sciences. The themes we deal with are relevant to everyone around the world and Wageningen, therefore, has a large international community and a lot to offer to international employees. Applicants from abroad moving to the Netherlands may qualify for a special tax relief, known as the 30% ruling. Our team of advisors on Dutch immigration procedures will help you with the visa application procedures for yourself and, if applicable, for your family.

Feeling welcome also has everything to do with being well informed. Wageningen University & Research's International Community page contains practical information about what we can do to support international employees and students coming to Wageningen. Furthermore, we can assist you with any additional advice and information about helping your partner to find a job, housing, schooling, and other issues.

Equal opportunities
Wageningen University & Research (WUR) employs a large number of people with very different backgrounds and qualities, who inspire and motivate each other. We want every talent to feel at home in our organisation and be offered the same career opportunities. We therefore especially welcome applications from people who are underrepresented at WUR. For more information please go to our inclusivity page. A good example of how WUR deals with inclusiveness can be read on the page working at WUR with a functional impairment.

More information

For more information about this position or the procedure, please contact Dr. Joost Keurentjes, Associate Professor, telephone +31 317 483149 or by e-mail Joost.Keurentjes@wur.nl, or Dr. Julian Verdonk, Assistant Professor, telephone +31 317 485660, julian.verdonk@wur.nl

Do you want to apply?
You can apply directly using the apply button on the vacancy page on our website which will allow us to process your personal information with your approval.

This vacancy will be listed up to and including 21 November 2022. We hope to schedule the first job interviews on 6, and 8 December 2022.

We are

The mission of Wageningen University & Research is “To explore the potential of nature to improve the quality of life”. Under the banner Wageningen University & Research, Wageningen University and the specialised research institutes of the Wageningen Research Foundation have joined forces in contributing to finding solutions to important questions in the domain of healthy food and living environment. With its roughly 30 branches, 7,200 employees (6,400 fte) and 13,200 students and over 150.000 participants to WUR’s Life Long Learning, Wageningen University & Research is one of the leading organisations in its domain. The unique Wageningen approach lies in its integrated approach to issues and the collaboration between different disciplines.

Read the 5 reasons why your future colleagues enjoy working at WUR and watch this video to get an idea of our green campus!

Apply now

Machine Learning Researcher

 Are you experienced in Machine Learning and data science? Would you like to add value to sustainable solutions for a better world? We, Wageningen University & Research (WUR), have a vacancy for a Machine Learning Researcher! Are you our new colleague?

WHAT WILL YOU DO?
As Machine Learning researcher at WUR, you will work within the research institute of Wageningen Food and Biobased Research (WFBR). You will contribute to data-driven solutions for our research in Biobased products and Fresh Food & Chains.

An example: it is difficult to know how the quality of fresh products develops during transportation. When the product arrives at its final destination, its reduced quality may be reflected in a reduced price, or worse: the product is wasted. Imagine that a batch of bananas is harvested in South Africa and transported in containers to the Netherlands. Data on temperature, ethylene and humidity are collected via sensors in the containers. What can you do with this information? The harvesting and transportation conditions can be used to develop a quality prediction model and to advise whether the bananas should already be sold in France - while the quality is still good - or whether they arrive in good shape for sale on the Dutch market. In this way, the prediction model you developed will help to reduce food waste and your knowledge contributes to create a more sustainable world.

Another example: Plant-based products (e.g. soy, pea) can be used after fermentation for specific meat- or dairy alternatives. In the fermentation process, every substrate and strain has different effects on the functionality of the fermented product. Understanding and optimising fermentation processes would traditionally require an experiment for every possible combination and condition. This is very time-consuming and therefore not feasible. By using machine learning in combination with data from previous experiments, predictions can be made about the benefits of new combinations. These predictions will be the foundation for new innovative and sustainable products.

Will it be a challenge? Yes! Do you have to do this on your own? No! You will work together in a team. You will work on multiple different projects where the software development will be done in an Agile way. Knowledge sharing is the key to successful projects and teamwork. To achieve this success, we meet each other multiple times a week in Wageningen.
WFBR is a research institute with funding from market and government parties. To obtain this funding we need to do acquisition. You will also work with our business developers to come up with feasible ideas for innovative solutions. Once a project is granted we expect you to lead it, now or in the future. This will be based on your experience and ambition.
 

We ask

You have:

• an MSc or PhD in a relevant field such as Artificial Intelligence, computer science, mathematics, etc. added with at least 4 years of work experience (or PhD research) in data science/AI;
• proven experience in AI methodology: e.g. feature engineering, model selection, model validation, supervised/unsupervised learning, optimization, knowledge engineering, (deep) neural networks, probabilistic methods, statistics, visualizations, time-series analysis, natural language processing;
• proficient in AI software development:
  • developing and maintaining code in Python using common AI-libraries
  • algorithm and architecture design
  • software testing
  • version management (Git, SVN)
  • database integration (querying SQL / SPARQL);

• knowledge on semantic technologies such as RDF, RDFs, OWL is a plus;
• knowledge of the Microsoft Azure cloud platform and API development is a plus.

Besides your technical knowledge, we also expect you to be communicative, fluent in English (C1 level), innovative and a real team player.
 

We offer

Wageningen University & Research offers excellent terms of employment. A few highlights from our Collective Labour Agreement include:

• working hours that can be discussed and arranged so that they allow for the best possible work-life balance;
• the option to accrue additional compensation hours by working more, up to 40 hours per week;
• sabbatical leave, study leave, and partially paid parental leave;
• there is a strong focus on vitality and you can make use of the sports facilities available on campus for a small fee;
• 8% holiday allowance in May;
• a fixed December bonus of 4%;
• excellent pension scheme.

In addition to these first-rate employee benefits, you will of course receive a good salary. We offer, depending on your experience, a competitive gross salary of between €2949,- and €5479,- for a full-time working week of 36 hours, in accordance with the CLA Wageningen Research (scale 10 - 11). Additionally, a contract for 32 hours a week can be discussed.

Wageningen University & Research encourages internal advancement opportunities and mobility with an internal recruitment policy. There are plenty of options for personal initiative in a learning environment, and we provide excellent training opportunities. We are offering a multi-faceted position in an international environment with a pleasant and open working atmosphere.

You are going to work at the greenest and most innovative campus in Holland, and at a university that has been chosen as the “Best University” in the Netherlands for the 17^th consecutive time.

Coming from abroad
Wageningen University & Research is the university and research centre for life sciences. The themes we deal with are relevant to everyone around the world and Wageningen, therefore, has a large international community and a lot to offer to international employees. Applicants from abroad moving to the Netherlands may qualify for a special tax relief, known as the 30% ruling. Our team of advisors on Dutch immigration procedures will help you with the visa application procedures for yourself and, if applicable, for your family.

Feeling welcome also has everything to do with being well informed. Wageningen University & Research's International Community page contains practical information about what we can do to support international employees and students coming to Wageningen. Furthermore, we can assist you with any additional advice and information about helping your partner to find a job, housing, schooling, and other issues.

 

More information

Do you want more information?
For more information about this position, please contact Henk Wensink, R&D Manager, telephone: +31 317 485586 or by e-mail: henk.wensink@wur.nl.
 
For more information about the procedure, please contact Rutger Voorrips, Recruiter, by e-mail: rutger.voorrips@wur.nl or by phone: +31 317 480571.
 
Do you want to apply?
You can apply directly using the apply button on the vacancy page on our website which will allow us to process your personal information with your approval. Please specify your technical skills in your resume so we can see which boxes you tick from our requirements.
This vacancy will be listed up to and including Wednesday 16^th 2022.
 
Equal opportunities
Wageningen University & Research (WUR) employs a large number of people with very different backgrounds and qualities, who inspire and motivate each other. We want every talent to feel at home in our organisation and be offered the same career opportunities. We therefore especially welcome applications from people who are underrepresented at WUR. For more information please go to our inclusivity page. A good example of how WUR deals with inclusiveness can be read on the page working at WUR with a functional impairment.

We are

The mission of Wageningen University & Research is “To explore the potential of nature to improve the quality of life”. Under the banner Wageningen University & Research, Wageningen University and the specialised research institutes of the Wageningen Research Foundation have joined forces in contributing to finding solutions to important questions in the domain of healthy food and living environment. With its roughly 30 branches, 7,200 employees (6,400 fte) and 13,200 students and over 150.000 participants to WUR’s Life Long Learning, Wageningen University & Research is one of the leading organisations in its domain. The unique Wageningen approach lies in its integrated approach to issues and the collaboration between different disciplines.

Read the 5 reasons why your future colleagues enjoy working at WUR and watch this video to get an idea of our green campus!

We will recruit for the vacancy ourselves, so no employment agencies please. However, sharing in your network is appreciated.

 

Apply now

Postdoctoral position in immunology – EU-funded project on T cell immunity against respiratory viruses

 We are looking for an ambitious postdoctoral fellow with solid human immunology skills to join our EU-funded project (REACT) on cell-mediated immunity against respiratory viral infections. We offer an international collaborative environment in a rapidly moving research frontier. The successful candidate will be part of the EU cluster of researchers working at Karolinska Institutet (KI) and Denmark Technical University (DTU).

Your mission

Within the EU consortia, we (Dr. Marcus Buggert, KI, and Dr. Sine Reker Hadrup, DTU) oversee the human studies on virus-specific T cell immunity. These studies are translational and involve using cutting-edge barcoding single-cell technologies, including high-parameter flow cytometry, RNA-seq, TCR-seq, proteomics, and gene-editing analysis to dissect the heterogeneity and function of memory T cell immunity.

The postdoctoral candidate will work with immunological questions centered on respiratory tract infections, including SARS-CoV-2, Influenza A, and RSV. The fellow will work in close conjunction with researchers at DTU during the first year(s) and use next-generation barcoding technologies to decipher similarities and differences in how T cells recognize different respiratory viruses after vaccination and infection. The candidate will also work in close collaboration with various members of the group at KI to set up barcoding and other single-cell technologies to dissect different functions of human memory T cell biology in viral disease. As such, we are seeking a postdoctoral candidate with a Ph.D. in the field of T cell immunology who will work as an integrated member of our teams at KI and DTU, with the capacity to implement new technologies to drive his/her own projects forward.

Your profile

To be eligible for employment as a postdoctoral candidate, the candidate should have demonstrated research expertise and documented research experience in human and/or T cell immunology during or after the Ph.D. defense. A strong candidate should preferably have a solid background in studies of human T cell biology in viral infections, e.g., SARS-CoV-2. Experience in sequencing techniques, flow cytometry, and virus-specific T cell technologies will also be considered merits. Applicants should have first-author publications in recognized peer-reviewed journals. Fluency in English is a requirement.

It is particularly meritorious that the applicant has

•  Been trained in immunology during her/his Ph.D. studies
•  Publications in the field of human T cell immunology
•  Extensive knowledge in multiparametric flow cytometry
•  Antigen-specific T cell staining (e.g., tetramers, intracellular cytokines)
•  Extensive BSL-II cell culture background
•  Next-generation sequencing skill sets (e.g., preparation of RNAseq libraries)
•  Basic molecular biology techniques (e.g., PCR)
•  Statistical knowledge

It is meritorious that the applicant has

•  Trained in biotechnology/biomedicine during her/his Master’s studies
•  Bioinformatics analysis of single-cell flow cytometry and sequencing data

What do we offer?

Karolinska Institutet is one of the world's leading medical universities. Our vision is to pursue the development of knowledge about life and to promote better health for all. At Karolinska Institutet, we conduct innovative medical research and provide the largest range of biomedical education in Sweden. Karolinska Institutet is a state university, which entitles employees to several benefits such as extended holiday and a generous occupational pension. Employees also have free access to our modern gym and receive reimbursements for medical care.

Location: Flemingsberg 

Read more about the Center for Infectious Medicine
Read more about the Buggert research group
10 reasons to work at KI

 

Application

An employment application must contain the following documents in English or Swedish:

A complete resumé, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work A complete list of publications A summary of current work (no more than one page)

Welcome to apply at the latest 2022-11-03

The application is to be submitted through the Varbi recruitment system.

 

Want to make a difference? Join us and contribute to better health for all

Type of employment	Temporary position longer than 6 months
Contract type	Full time
First day of employment	2023-01-01
Number of positions	1
Working hours	100%
City	Huddinge
County	Stockholms län
Country	Sweden
Reference number	STÖD 2-3890/2022
Contact	Marcus Buggert, marcus.buggert@ki.se
Union representative	Elisabeth Henriksson OFR, elisabeth.henriksson@ki.se Belinda Pannagel SACO, belinda.pannagel@ki.se Mari Giljam, OFR, mari.giljam@ki.se
Published	06.Oct.2022
Last application date	06.Nov.2022 11:59 PM CET

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Research Specialist in Stem Cell Biology

 We are looking for an experienced and ambitious researcher in stem cell biology. We offer a fun, collaborative and stimulating work environment as well as career development track opportunities towards Senior Research Specialist and Associate Professor (docent). The successful candidate will be part of a research team working on innovative projects with industry collaboration and real clinical applications.

The Research Unit

The Center for Hematology and Regenerative medicine, HERM, is a research unit within the Department of Medicine Huddinge with a focus on translational hematology and immunology. HERM is located in the NEO building and consists of a mix of clinical and preclinical research groups, each with a focus on clinically relevant questions in hematology, stem cell biology and immunology, including basic immunology, immunodeficiency and transfusion immunology.

The research environment at HERM is very vibrant and collaborative. The equipment is state of the art. We have nearby core facilities focusing on advanced FACS, single cell transcriptomics and live cell imaging. Each week, there are seminars with distinguished invited speakers from all over the world. Every year, there are retreats and locally arranged conferences. For example, the Stratregen conference in October 2022, the Young Hematologist symposium and the local NEO building retreat.

Our team currently has three members. We belong to the lab of Professor Petter Höglund. We have close collaboration with Dr Joel Nordin’s research group which focuses on exosomes and strategies to genetically modify stem cells for clinical purposes. We are also working closely together with Dr Hong Qian’s group, which specializes on the leukemia niche.

 

Description of the subject area

We are interested in the interaction between hematopoietic stem cells and the extracellular matrix. Using 10X single sequencing + antibody tags, we are characterizing the full spectrum of adhesion molecules that are expressed by Hematopoietic Stem and different lineages of Progenitor Cells. We are also planning to use SmartSeq single cell sequencing to characterize Mesenchymal Stem Cells from human bone marrow. 

Hematopoietic Stem and Progenitor Cells (HSPCs) are adherent cells in the bone marrow, and we hypothesize that integrin-mediated signaling is important for maintaining them ex vivo. We are focused on human HSPCs and we are taking a systematic approach to tackle this research question. We have a VINNOVA innovation-project together with the company Cellevate AB, which manufactures 3D scaffolds for bioreactor purposes. The idea is to customize 3D scaffolds with different cell adhesive molecules and integrin ligands, suitable for HSPCs. Using customized 3D scaffolds, we plan to systematically study the biological effects of stimulating different integrin ligands on stem cells.

The clinical applications we are working on are ex vivo expansion of stem cells and selective differentiation of stem cells to different lineages, mainly granulocyte and megakaryocyte progenitor cells. The goal is to establish a method for transplanting short-lived progenitors to patients with neutropenia and transfusion-refractory thrombocytopenia. These will give a transient engraftment for a week and protect the neutropenic/thrombocytopenic patient from infections and bleeding during that time. As above-mentioned, from a scientific perspective, this will require us to systematically dissect the role of cell-adhesion on intracellular signaling pathways in HSPCs.

• What adhesion molecules are expressed on human HSPCs.
• Do different integrins elicit different signaling cascades?
• How do other cell adhesion molecules like Syndecans modulate integrin signaling?
• How does integrin signaling interact with growth factors to determine stemness and direction of differentiation?

We work with human stem cell sources. Our research team has unlimited access to large amounts of Peripheral Blood Mobilized CD34+ stem cells from healthy donors of different ages. We also have access to human Bone Marrow and Umbilical Cord Blood stem cells, albeit less frequently (10-12 times a year). In parallel, we are also working on establishing a biobank with frozen AML and KML blast to translate the findings to haematological malignancies.

Your mission

The focus of your duties is to drive research projects on integrin signaling in Stem Cells as well as developing methods to harness integrin signaling in ex vivo culture of stem cells for clinical purposes. An additional key task is to give intellectual, practical and administrative support to other members of the research group. We are seeking one Research Specialist with PhD and several years of laboratory research with focus on stem cell biology, who will work as an integrated research specialist in our team, being involved in several ongoing projects. Excellent communication skills and fluency in English is essential. Your daily tasks will include:

• Elaboration of scientific hypothesis, experimental design
• Supervising students
• Performing Flow cytometry and other routine molecular biology work
• Data Analysis
• Presentation and publication of results 

Eligibility requirements

To be eligible for employment as a Research Specialist, in addition to holding a Degree of Doctor, PhD, or having equivalent scientific expertise, the applicant must have demonstrated research expertise as well as have documented research experience after defending their doctoral dissertation.

You must have a PhD in the field of Immunology, Cell biology or Stem cell biology. 

The candidate should have been trained in Stem Cell Biology during their masters- and PhD studies. The candidate should fully master (requirement) cell culture (cell lines, primary stem cells cells, DNA/RNA isolations, ELISA, multi-colour flow cytometry, immunofluorescence, immunoprecipitation, luciferase reporter assays, PCR, protein purifications, quantitative PCR, reverse transcriptase PCR, SDS PAGE, size exclusion chromatography, lentiviral transductions, transfections, and western blotting).

Experience with proteomics and RNA-seq is a merit.

Ability to formalize biological questions into experimental model systems in order to consult and advise on experimental design for team members before data generation is another merit. The candidate should be self-motivated, have good communications skills and a proven ability to interact effectively and work productively in an interdisciplinary team. Fluency in English is a requirement. Experience of European academical system is an added value.

Assessment criteria

It is particularly meritorious that the applicant has shown

• Experience in using a variety of molecular biology technologies to study stem cells
• Experience supervising students
• Experience with multi-color Flow Cytometry
• Profound knowledge of Stem Cell Biology
• Experience leading a team or project management
• Experience collaborating successfully within a team
• Scientific maturity
• Previous experience analyzing single cell sequencing data or other large data sets
• Experience working with and culturing primary cells

It is meritorious that the applicant has shown

• Leadership skills
• Organizational skills
• Creativity and problem-solving skills 

After an overall assessment of the expertise and merits of the applicants in relation to the subject area, Karolinska Institutet will determine which of them has the best potential to contribute to a positive development of the activities at KI.

Personal qualities

We put great emphasis on personal suitability for the position. To succeed in the role, you need to be self-directed and independent in your way of working. Furthermore, we see that you, the applicant, have a solid sense of creativity and would like to exceed the expectations of your colleagues with a pleasant, collaborative, and professional manner. In conclusion, we are looking for you who are self-motivated and curious and have the will and ability to take your own initiative and push your own work forward.

What do we offer?

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world's leading medical universities. Here, we conduct successful medical research and hold the largest range of medical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Several of the people you meet in healthcare are educated at KI. A close relationship with the health care providers is important for creating groundbreaking top quality education and research. Karolinska Institutet is also a state university, which entitles you to several benefits through our collective agreement.

Location: Flemingsberg

Read more about the Department of Medicine, Huddinge (MedH)
Choose to work at KI - Ten reasons why

Application

We prefer that Your application is written in English, but You can also apply in Swedish. An application must contain the following documents: Resumé, qualifications and description of planned research, presented in accordance with Karolinska Institutet's qualifications portfolio.

Welcome to apply at the latest 30/11-22

The application must be submitted through the Varbi recruitment system.

In the case of permanent employment, Karolinska Institutet applies a 6-month probationary period.

Want to make a difference? Join us and contribute to better health for all

Type of employment	Permanent position
Contract type	Full time
First day of employment	According to agreement
Salary	Månadslön
Number of positions	1
Working hours	100 %
City	Flemingsberg
County	Stockholms län
Country	Sweden
Reference number	STÖD 2-3465/2022
Contact	Roland Fiskesund, roland.fiskesund@ki.se
Union representative	Belinda Pannagel, SACO, belinda.pannagel@ki.se Elisabeth Henriksson, OFR, Elisabet.Henriksson@ki.se Mari Gilljam, OFR, Mari.Gilljam@ki.se
Published	06.Sep.2022
Last application date	30.Nov.2022 11:59 PM CET

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Postdoctoral studies in genomics and transcriptomics

 The Department of Microbiology, Tumor and Cell Biology (MTC) at Karolinska Institutet in Stockholm conducts research and teaching in infection biology, immunology, cell biology and cancer. Our keywords are interdisciplinarity, clinically based basic research and national and international cooperation.

The research group of Dr Claudia Kutter seeks a Postdoc (either computational or computational/experimental) in the field of functional genomics and RNA biology. The Kutter lab has a track record in deciphering molecular mechanism by which RNAs (i.e. long noncoding, transfer and small RNA) regulate genes and genome structure in mammalian somatic tissue and in the germline (Geng et al. Genome Research 2022, Søndergaard et al. Gut, 2022, Gao et al. Genome Research 2022). As a Postdoc you will be part of a multidisciplinary and collaborative research team active within the fields of chromatin and RNA biology, functional and/or comparative genomics.

Your mission

As a member of the Kutter lab, you will apply, optimize and integrate novel transcriptome-wide approaches (based on single cell RNA-sequencing) to study transcript regulation using data obtained from mouse studies and patients. This project focusses on the roles of regulatory RNAs. 

The Kutter lab interrogates genome- and transcriptome-wide regulation and functionality by employing a combination of next generation sequencing technologies (both bulk and single-cell) and high-throughput genetic screening approaches, develops computational methods, along with applying experimental techniques. The group uses an integrative and collaborative approach, works closely with computational and experimental groups at KI, Science for Life Laboratory (SciLifeLab), and other local and international research groups. Frequent courses are provided on campus. Additional professional training is available through summer schools and recurrent workshops.

The laboratory is located at SciLifeLab on the Karolinska Institute campus in Stockholm. SciLifeLab offers an attractive research environment, provides state-of-the-art instrumentation and core facilities, and is home to the second largest sequencing cluster in Europe. SciLifeLab is a joint effort between Karolinska Institute, the Swedish Royal Institute of Technology, and Stockholm University. It hosts research groups with diverse backgrounds and expertise, creating a unique interface between basic biology, genomics, bioengineering, drug discovery, and translational medicine.

Your profile

Qualified to be employed as a postdoctor is one who has obtained a doctorate or has equivalent scientific competence. It is considered as an advantage if you have completed your doctoral degree within the last three years, if there are special reasons, your degree may have been completed earlier. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) date of employment. This must be substantiated by the applicant's main supervisor, director or equivalent.

A strong background in genomics, computational biology, and/or statistics as well as experience in high-throughput sequence and gene expression data analysis techniques is essential for the position. Excellent skills in programming (primarily Python, R/Bioconductor, UNIX), knowledge of biological databases and data integration as well as data visualization is required. As a Postdoc you will take a strong lead in the project design and management as well as data generation, analyses, and interpretation, participate in the general duties of the team and collaborate with other team members. You are expected to report the scientific results leading to scientific manuscripts, attending scientific meetings, and effectively communicate with peers. The ability to work in a highly interdisciplinary and international environment, and to engage in continuous professional development is a must.

What do we offer?

A creative and inspiring environment with wide-ranging expertise and interests.

Karolinska Institutet is one of the world's leading medical universities. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. At KI, you get to meet researchers working with a wide range of specialisms and methods, giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations, which have pushed KI to where it is today, at the forefront of global research. Several of the people you meet in healthcare are educated at KI. A close relationship with the health care providers is important for creating groundbreaking top quality education and research. Karolinska Institutet is also a state university, which entitles you to several benefits through our collective agreement.

Location: Solna, Science for Life Laboratory

https://ki.se/en/mtc/kutter-group-regulatory-transcriptions

https://www.scilifelab.se/researchers/claudia-kutter/

Application

An employment application must contain the following documents in English or Swedish:

A complete resumé, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work A complete list of publications A summary of current work (no more than one page)

Copy of Phd-degree

Welcome to apply at the latest 2022-11-21

The application is to be submitted through the Varbi recruitment system.

Want to make a difference? Join us and contribute to better health for all

Type of employment	Temporary position longer than 6 months
Contract type	Full time
First day of employment	According to agreement
Salary	Monthly salary
Number of positions	1
Working hours	100 %
City	Solna
County	Stockholms län
Country	Sweden
Reference number	STÖD 2-3982/2022
Contact	Claudia Kutter, claudia.kutter@ki.se
Union representative	Henry Wölling, henry.wolling@ki.se Carina Ekelund, carina.eklund@ki.se Taher Darreh-Shori, taher.darreh-shori@ki.se
Published	14.Oct.2022
Last application date	21.Nov.2022 11:59 PM CET

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