Uppsala University is a comprehensive research-intensive university with a strong international standing. Our ultimate goal is to conduct education and research of the highest quality and relevance to make a long-term difference in society. Our most important assets are all the individuals whose curiosity and dedication make Uppsala University one of Sweden’s most exciting workplaces. Uppsala University has over 45,000 students, more than 7,000 employees and a turnover of around SEK 7 billion.
The Department of Cell and Molecular Biology is one of the most international, broad and distinguished molecular bioscience departments in Europe. The department comprises six research programs with about 220 employees (http://www.icm.uu.se). The PhD position is available in Jens Carlsson’s group in the computational biology and bioinformatics programme. Jens Carlsson’s research focuses on using molecular modeling to study protein-ligand interactions, in particular G protein-coupled receptors (GPCRs) and their interactions with drugs. The GPCR superfamily constitutes the largest group of human membrane proteins and plays key roles in physiological processes. The Carlsson group uses structure-based models to understand receptor function and to design ligands of these pharmaceutically important targets, often in close collaboration with experimental groups. The Carlsson group is an international research team and is also part of the Science for Life Laboratory (http://www.scilifelab.se/). Visit the group website for more information (www.carlssonlab.org).
General description: Computational modeling has become an important tool for understanding biological processes at the molecular level. The project is focused on developing and applying methods to study how neurotransmitters bind to receptors using molecular simulations. A central aim of the project is to understand the evolution of receptors and how they are able to distinguish between similar neurotransmitters such as dopamine and adrenaline. The project will also involve computer-aided design of ligands with specific pharmacological profiles.
The project will be carried out in close collaboration with experimental and theoretical research groups at Uppsala University, KTH Royal Institute of Technology, and Karolinska Institutet. Our research project is also described on the Knut and Alice Wallenberg foundation’s website: https://kaw.wallenberg.org/en/research/signal-pathways-better-therapeutics.
Duties: The PhD student shall primarily focus on postgraduate studies, but other duties related to teaching and administrative work may be involved (up to a maximum of 20% of the time). Information about doctoral education, eligibility requirements and admission rules can be found at the faculty website: https://teknat.uu.se/education/postgraduate/.
Requirements: The applicant must hold a master’s degree in biology, chemistry, pharmacy, physics or within another subject which the employer considers to be equivalent. The applicant must have good ability to work independently as well as in a group. Excellent written and oral knowledge of English is required as the work takes place in an international environment.
Additional qualifications: Experience in modeling of proteins (e.g. GPCRs), computer-aided drug design, molecular dynamics simulations, molecular docking, and scientific programming is preferred, but not required.
Rules governing PhD students are set out in the Higher Education Ordinance chapter 5, §§ 1-7 and in Uppsala University's rules and guidelines.
The application: Your application should include:
- A letter where you describe yourself, your research interest, and why you are interested in the position (max. 2 pages).
- A CV containing your education and other qualifications, and a description of knowledge relevant for the requirements of the position.
- A copy of your diplomas and your master thesis.
- Contact information to two reference persons.
Salary: According to local agreement for PhD students.
Starting date: As soon as possible or as otherwise agreed.
Type of employment: Temporary position according to the Higher Education Ordinance chapter 5 § 7.
Scope of employment: 100 %.
For further information about the position please contact: Jens Carlsson, jens.carlsson@icm.uu.se, Tel: +46 (0)72 227 7976.
Please submit your application by August 2 2021, UFV-PA 2021/2688.
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Submit your application through Uppsala University's recruitment system.
Placement: Department of Cell and Molecular Biology
Type of employment: Full time , Temporary position longer than 6 months
Pay: Fixed salary
Number of positions: 1
Working hours: 100 %
Town: Uppsala
County: Uppsala län
Country: Sweden
Union representative: ST/TCO tco@fackorg.uu.se
Seko Universitetsklubben seko@uadm.uu.se
Saco-rådet saco@uadm.uu.se
Number of reference: UFV-PA 2021/2688
Last application date: 2021-08-02
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