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Project title: Late epigenetic effects in vivo after low to medium dose exposure to radioiodine

Job assignments

The PhD education in Medical Science comprises carrying out a scientific project and completing at least 30 credits of courses at third-cycle level. The doctoral student must also write a scientific compilation thesis or monograph corresponding to at least 120 credits. For more information about third-cycle studies at Sahlgrenska Academy, see https://www.gu.se/en/sahlgrenska-akademin/doctoral-studies

Project: The thyroid gland is a relatively radiosensitive organ important to protect from ionizing radiation, and especially after exposure to radioiodine. The mechanisms behind radiobiological effects are still little known. Current molecular methods are very useful for mechanistic studies on cells and tissues. The present project will focus on late epigenetic effects. Epigenetic modifications are changes in expression of genes without any alteration in the DNA sequence and may be inherited. It has been proposed that epigenetic modulation after irradiation is most important for late tissue responses and specifically cancer induction for e.g. thyroid cancer. As far as we know, detailed whole-genome epigenetic effects of ionizing radiation on thyroid tissue in vivo have not been presented. The overall aim of the project is to examine epigenetic effects long time after internal exposure to low to medium dose of 131I on normal thyroid tissue in vivo. Focus will initially be on DNA methylation, but may include other mechanisms e.g. miRNA induction. The results will then be compared with gene and protein expression data, ideally from the same tissue samples, in order to find correlations between epigenetic and expression data and to define and validate potential biomarkers.  

Third-cycle studies are equivalent to four year full-time and lead to a Degree of Doctor. Those appointed to doctoral studentships shall primarily devote themselves to their studies. Those appointed to doctoral studentships may, however, work to a limited extent with educational tasks, research and administration (departmental duties). Before a PhD degree has been awarded, duties of this kind may not comprise more than 20 per cent of a full-time post.

Eligibility

To be eligible for third-cycle studies, the applicant must meet both the general and specific entry requirements.

A person meets the general entry requirements for third-cycle studies if he or she:
1. has been awarded a second-cycle qualification
2. has satisfied the requirements for courses comprising at least 240 credits of which at least 60 credits were awarded in the second-cycle, or
3. has acquired substantially equivalent knowledge in some other way in Sweden or abroad

A person meets the specific entry requirements for third-cycle studies in Medical Science if he or she has successfully completed the English B/6 course or is considered to have acquired equivalent knowledge through previous studies

Assessment

In selecting between applicants who meet the general and specific entry requirements, their ability to benefit from third-cycle studies shall be taken into account. The assessment shall attach particular importance to documented qualifications for:
- specific knowledge and skills within the subject area and related research fields
- experience of scientific theory and relevant research methodology
- scientific analysis and presentation verified through thesis, degree project, scientific journals or the like.

Documented experience of work with molecular biology methods on DNA, RNA and protein levels, as well as analysis of microarray data is of merit. Hands on experience of handling of radioactivity is valuable.

Employment

After admission to third-cycle studies you will be appointed to doctoral studentship. Regulations for employment of doctoral students are given in SFS 1993:100. The initial appointment may apply for no longer than one year. An appointment may be renewed for no more than two years at a time. A person may be appointed to a doctoral studentship for a total of eight years. The total employment period may, however, not exceed the time corresponding to full-time third-cycle study for four years.

Location: Sahlgrenska Academy, Institute of Clinical Sciences, Department of Radiation Physics. Extent: 100%. First day of employment: as agreed. 

Salaries for doctoral students are regulated in a local agreement at the University. 

For further information regarding the position

For more information about the project please contact the principal supervisor,
Eva Forssell-Aronsson, professor, Institute of Clinical Sciences, 
phone: +46-703722626, e-mail: eva.forssell_aronsson@radfys.gu.se 

Unions

Union representatives at the University of Gothenburg:
https://www.gu.se/en/about-the-university/work-at-the-university-of-gothenburg/how-to-apply

Information for International Applicants

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https://www.gu.se/en/about-the-university/welcome-services

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How to apply

In order to apply for a position at the University of Gothenburg, you have to register an account in our online recruitment system. It is the responsibility of the applicant to ensure that the application is complete in accordance with the instructions in the job advertisement, and that it is submitted before the deadline.

You must include the following, in pdf format

  • Personal letter
  • CV
  • Diploma and transcripts showing that you meet with the general entry requirement
  • Proof of completion of  English 6 course or the acquired equivalent knowledge through previous studies

If your degree is from a university outside of Sweden, make sure that you attach a diploma and full transcripts that makes assessing your degree easier.  

If your degree has not been verified by a Swedish authority you need to provide contact details to the issuing university, registrar or similar, that can verify the degree at our request.

For information on what you need to submit in order to fulfill the English language requirement see https://www.universityadmissions.se/en/entry-requirements/english-language-requirements/

Closing date: 2022-01-16

 

The University of Gothenburg promotes equal opportunities, equality and diversity.

Applications will be destroyed or returned (upon request) two years after the decision of employment has become final. Applications from the employed and from those who appeal the decision will not be returned.

In connection to this recruitment, we have already decided which recruitment channels we should use. We therefore decline further contact with vendors, recruitment and staffing companies.