Medizinbereich Spezialisierte Chirurgie und Medizin
Department of Dermatology, in Bern
Entry per 01.03.2022 or by appointment
Temporary position 3 years
As a leading university hospital with a rich tradition, the Inselspital is part of the Insel Group and is a centre of medical expertise and high technology with an international reputation as well as being a first-class training and research centre.
The laboratory of the Department of Dermatology is focused on the study of human T helper cells and their role in inflammatory skin disease. We aim to better understand the mechanisms of skin inflammation and to create new therapeutic strategies.
The challenge
Skin-resident memory T (TRM) cells can persist long-term in the skin where they provide immune protection against infections. However, their aberrant activation can cause chronic inflammatory skin disease. Current treatments suppress inflammation, but fail to cure patients long-term. Thus, there is a need for a better understanding of chronic inflammation to develop curative therapies.
Recent findings suggest that the metabolic transcription factor PPAR-γ plays a crucial role in TRM-driven skin disease. Therefore, we aim to address these questions:
How does PPAR-γ regulate cellular metabolism & function in TH cells from skin?
How does the metabolic environment in skin disease influence TH cells?
How can we leverage the modulation of TH cell metabolism for therapy?
Recent findings suggest that the metabolic transcription factor PPAR-γ plays a crucial role in TRM-driven skin disease. Therefore, we aim to address these questions:
How does PPAR-γ regulate cellular metabolism & function in TH cells from skin?
How does the metabolic environment in skin disease influence TH cells?
How can we leverage the modulation of TH cell metabolism for therapy?
Your profile
- European academic degree in natural sciences (MSc) acceptable for matriculation at a Swiss University
- Fluent in English
- Dedicated to science and academia
- Theoretical & practical skills in immunology, molecular, & cellular biology
The package
Our team offers a dynamic and aspiring research environment. Close collaborations with local and inter-national laboratories guarantees access to state of the art know-how and infrastructure.
Contact and application
For further information, please contact: Prof. Dr. med. Dr. phil. Christoph Schlapbach,
Assistant Professor of Department of Dermatology, e-mail christoph.schlapbach@insel.ch
Your application should include:
Please only apply online: Code number 13002
Assistant Professor of Department of Dermatology, e-mail christoph.schlapbach@insel.ch
Your application should include:
- Curriculum vitae with a brief description of laboratory experience
- Letters of support with the address and contact information of at least one referee
Please only apply online: Code number 13002
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